8 results on '"de la Prida, Liset M"'
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2. The continued need for animals to advance brain research
- Author
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Afd Pharmacology, AISS Behaviour Neuroscience, dASS BW-1, Sub Cell Biology, Pharmacology, Celbiologie, Homberg, Judith R, Adan, Roger A H, Alenina, Natalia, Asiminas, Antonis, Bader, Michael, Beckers, Tom, Begg, Denovan P, Blokland, Arjan, Burger, Marilise E, van Dijk, Gertjan, Eisel, Ulrich L M, Elgersma, Ype, Englitz, Bernhard, Fernandez-Ruiz, Antonio, Fitzsimons, Carlos P, van Dam, Anne-Marie, Gass, Peter, Grandjean, Joanes, Havekes, Robbert, Henckens, Marloes J A G, Herden, Christiane, Hut, Roelof A, Jarrett, Wendy, Jeffrey, Kate, Jezova, Daniela, Kalsbeek, Andries, Kamermans, Maarten, Kas, Martien J, Kasri, Nael Nadif, Kiliaan, Amanda J, Kolk, Sharon M, Korosi, Aniko, Korte, S Mechiel, Kozicz, Tamas, Kushner, Steven A, Leech, Kirk, Lesch, Klaus-Peter, Lesscher, Heidi, Lucassen, Paul J, Luthi, Anita, Ma, Liya, Mallien, Anne S, Meerlo, Peter, Mejias, Jorge F, Meye, Frank J, Mitchell, Anna S, Mul, Joram D, Olcese, Umberto, González, Azahara Oliva, Olivier, Jocelien D A, Pasqualetti, Massimo, Pennartz, Cyriel M A, Popik, Piotr, Prickaerts, Jos, de la Prida, Liset M, Ribeiro, Sidarta, Roozendaal, Benno, Rossato, Janine I, Salari, Ali-Akbar, Schoemaker, Regien G, Smit, August B, Vanderschuren, Louk J M J, Takeuchi, Tomonori, van der Veen, Rixt, Smidt, Marten P, Vyazovskiy, Vladyslav V, Wiesmann, Maximilian, Wierenga, Corette J, Williams, Bella, Willuhn, Ingo, Wöhr, Markus, Wolvekamp, Monique, van der Zee, Eddy A, Genzel, Lisa, Afd Pharmacology, AISS Behaviour Neuroscience, dASS BW-1, Sub Cell Biology, Pharmacology, Celbiologie, Homberg, Judith R, Adan, Roger A H, Alenina, Natalia, Asiminas, Antonis, Bader, Michael, Beckers, Tom, Begg, Denovan P, Blokland, Arjan, Burger, Marilise E, van Dijk, Gertjan, Eisel, Ulrich L M, Elgersma, Ype, Englitz, Bernhard, Fernandez-Ruiz, Antonio, Fitzsimons, Carlos P, van Dam, Anne-Marie, Gass, Peter, Grandjean, Joanes, Havekes, Robbert, Henckens, Marloes J A G, Herden, Christiane, Hut, Roelof A, Jarrett, Wendy, Jeffrey, Kate, Jezova, Daniela, Kalsbeek, Andries, Kamermans, Maarten, Kas, Martien J, Kasri, Nael Nadif, Kiliaan, Amanda J, Kolk, Sharon M, Korosi, Aniko, Korte, S Mechiel, Kozicz, Tamas, Kushner, Steven A, Leech, Kirk, Lesch, Klaus-Peter, Lesscher, Heidi, Lucassen, Paul J, Luthi, Anita, Ma, Liya, Mallien, Anne S, Meerlo, Peter, Mejias, Jorge F, Meye, Frank J, Mitchell, Anna S, Mul, Joram D, Olcese, Umberto, González, Azahara Oliva, Olivier, Jocelien D A, Pasqualetti, Massimo, Pennartz, Cyriel M A, Popik, Piotr, Prickaerts, Jos, de la Prida, Liset M, Ribeiro, Sidarta, Roozendaal, Benno, Rossato, Janine I, Salari, Ali-Akbar, Schoemaker, Regien G, Smit, August B, Vanderschuren, Louk J M J, Takeuchi, Tomonori, van der Veen, Rixt, Smidt, Marten P, Vyazovskiy, Vladyslav V, Wiesmann, Maximilian, Wierenga, Corette J, Williams, Bella, Willuhn, Ingo, Wöhr, Markus, Wolvekamp, Monique, van der Zee, Eddy A, and Genzel, Lisa
- Published
- 2021
3. The continued need for animals to advance brain research
- Author
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TN groep Adan, Brain, TN groep Meye, Homberg, Judith R, Adan, Roger A H, Alenina, Natalia, Asiminas, Antonis, Bader, Michael, Beckers, Tom, Begg, Denovan P, Blokland, Arjan, Burger, Marilise E, van Dijk, Gertjan, Eisel, Ulrich L M, Elgersma, Ype, Englitz, Bernhard, Fernandez-Ruiz, Antonio, Fitzsimons, Carlos P, van Dam, Anne-Marie, Gass, Peter, Grandjean, Joanes, Havekes, Robbert, Henckens, Marloes J A G, Herden, Christiane, Hut, Roelof A, Jarrett, Wendy, Jeffrey, Kate, Jezova, Daniela, Kalsbeek, Andries, Kamermans, Maarten, Kas, Martien J, Kasri, Nael Nadif, Kiliaan, Amanda J, Kolk, Sharon M, Korosi, Aniko, Korte, S Mechiel, Kozicz, Tamas, Kushner, Steven A, Leech, Kirk, Lesch, Klaus-Peter, Lesscher, Heidi, Lucassen, Paul J, Luthi, Anita, Ma, Liya, Mallien, Anne S, Meerlo, Peter, Mejias, Jorge F, Meye, Frank J, Mitchell, Anna S, Mul, Joram D, Olcese, Umberto, González, Azahara Oliva, Olivier, Jocelien D A, Pasqualetti, Massimo, Pennartz, Cyriel M A, Popik, Piotr, Prickaerts, Jos, de la Prida, Liset M, Ribeiro, Sidarta, Roozendaal, Benno, Rossato, Janine I, Salari, Ali-Akbar, Schoemaker, Regien G, Smit, August B, Vanderschuren, Louk J M J, Takeuchi, Tomonori, van der Veen, Rixt, Smidt, Marten P, Vyazovskiy, Vladyslav V, Wiesmann, Maximilian, Wierenga, Corette J, Williams, Bella, Willuhn, Ingo, Wöhr, Markus, Wolvekamp, Monique, van der Zee, Eddy A, Genzel, Lisa, TN groep Adan, Brain, TN groep Meye, Homberg, Judith R, Adan, Roger A H, Alenina, Natalia, Asiminas, Antonis, Bader, Michael, Beckers, Tom, Begg, Denovan P, Blokland, Arjan, Burger, Marilise E, van Dijk, Gertjan, Eisel, Ulrich L M, Elgersma, Ype, Englitz, Bernhard, Fernandez-Ruiz, Antonio, Fitzsimons, Carlos P, van Dam, Anne-Marie, Gass, Peter, Grandjean, Joanes, Havekes, Robbert, Henckens, Marloes J A G, Herden, Christiane, Hut, Roelof A, Jarrett, Wendy, Jeffrey, Kate, Jezova, Daniela, Kalsbeek, Andries, Kamermans, Maarten, Kas, Martien J, Kasri, Nael Nadif, Kiliaan, Amanda J, Kolk, Sharon M, Korosi, Aniko, Korte, S Mechiel, Kozicz, Tamas, Kushner, Steven A, Leech, Kirk, Lesch, Klaus-Peter, Lesscher, Heidi, Lucassen, Paul J, Luthi, Anita, Ma, Liya, Mallien, Anne S, Meerlo, Peter, Mejias, Jorge F, Meye, Frank J, Mitchell, Anna S, Mul, Joram D, Olcese, Umberto, González, Azahara Oliva, Olivier, Jocelien D A, Pasqualetti, Massimo, Pennartz, Cyriel M A, Popik, Piotr, Prickaerts, Jos, de la Prida, Liset M, Ribeiro, Sidarta, Roozendaal, Benno, Rossato, Janine I, Salari, Ali-Akbar, Schoemaker, Regien G, Smit, August B, Vanderschuren, Louk J M J, Takeuchi, Tomonori, van der Veen, Rixt, Smidt, Marten P, Vyazovskiy, Vladyslav V, Wiesmann, Maximilian, Wierenga, Corette J, Williams, Bella, Willuhn, Ingo, Wöhr, Markus, Wolvekamp, Monique, van der Zee, Eddy A, and Genzel, Lisa
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- 2021
4. Explorers of the cells: Toward cross-platform knowledge integration to evaluate neuronal function.
- Author
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de la Prida, Liset M. and Ascoli, Giorgio A.
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EXPLORERS , *NEURONS , *OPTOGENETICS , *OSCILLATIONS - Abstract
In this issue of Neuron , Petersen et al. (2021) introduce CellExplorer, an open-source tool to integrate neurophysiological metrics of neuronal activity from circuits to behavior. Together with other neuroinformatic resources, it may facilitate community-based multidisciplinary characterization of brain cell types. [ABSTRACT FROM AUTHOR]
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- 2021
- Full Text
- View/download PDF
5. Inhibitory conductance controls place field dynamics in the hippocampus.
- Author
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Valero M, Navas-Olive A, de la Prida LM, and Buzsáki G
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- Action Potentials physiology, Hippocampus physiology, Interneurons physiology, Pyramidal Cells physiology, Synaptic Transmission, Models, Neurological, Theta Rhythm physiology
- Abstract
Hippocampal place cells receive a disparate collection of excitatory and inhibitory currents that endow them with spatially selective discharges and rhythmic activity. Using a combination of in vivo intracellular and extracellular recordings with opto/chemogenetic manipulations and computational modeling, we investigate the influence of inhibitory and excitatory inputs on CA1 pyramidal cell responses. At the cell bodies, inhibition leads and is stronger than excitation across the entire theta cycle. Pyramidal neurons fire on the ascending phase of theta when released from inhibition. Computational models equipped with the observed conductances reproduce these dynamics. In these models, place field properties are favored when the increased excitation is coupled with a reduction of inhibition within the field. As predicted by our simulations, firing rate within place fields and phase locking to theta are impaired by DREADDs activation of interneurons. Our results indicate that decreased inhibitory conductance is critical for place field expression., Competing Interests: Declaration of interests The authors declare no competing interests., (Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.)
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- 2022
- Full Text
- View/download PDF
6. A protocol to extract cell-type-specific signatures from differentially expressed genes in bulk-tissue RNA-seq.
- Author
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Marquez-Galera A, de la Prida LM, and Lopez-Atalaya JP
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- Humans, RNA-Seq, Exome Sequencing, Brain, Epilepsy genetics
- Abstract
Bulk-tissue RNA-seq is widely used to dissect variation in gene expression levels across tissues and under different experimental conditions. Here, we introduce a protocol that leverages existing single-cell expression data to deconvolve patterns of cell-type-specific gene expression in differentially expressed gene lists from highly heterogeneous tissue. We apply this protocol to interrogate cell-type-specific gene expression and variation in cell type composition between the distinct sublayers of the hippocampal CA1 region of the brain in a rodent model of epilepsy. For complete details on the use and execution of this protocol, please refer to Cid et al. (2021)., Competing Interests: The authors declare no competing interests., (© 2022 The Authors.)
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- 2022
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7. The continued need for animals to advance brain research.
- Author
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Homberg JR, Adan RAH, Alenina N, Asiminas A, Bader M, Beckers T, Begg DP, Blokland A, Burger ME, van Dijk G, Eisel ULM, Elgersma Y, Englitz B, Fernandez-Ruiz A, Fitzsimons CP, van Dam AM, Gass P, Grandjean J, Havekes R, Henckens MJAG, Herden C, Hut RA, Jarrett W, Jeffrey K, Jezova D, Kalsbeek A, Kamermans M, Kas MJ, Kasri NN, Kiliaan AJ, Kolk SM, Korosi A, Korte SM, Kozicz T, Kushner SA, Leech K, Lesch KP, Lesscher H, Lucassen PJ, Luthi A, Ma L, Mallien AS, Meerlo P, Mejias JF, Meye FJ, Mitchell AS, Mul JD, Olcese U, González AO, Olivier JDA, Pasqualetti M, Pennartz CMA, Popik P, Prickaerts J, de la Prida LM, Ribeiro S, Roozendaal B, Rossato JI, Salari AA, Schoemaker RG, Smit AB, Vanderschuren LJMJ, Takeuchi T, van der Veen R, Smidt MP, Vyazovskiy VV, Wiesmann M, Wierenga CJ, Williams B, Willuhn I, Wöhr M, Wolvekamp M, van der Zee EA, and Genzel L
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- Animals, Animal Experimentation, Brain, Neurosciences
- Abstract
Policymakers aim to move toward animal-free alternatives for scientific research and have introduced very strict regulations for animal research. We argue that, for neuroscience research, until viable and translational alternatives become available and the value of these alternatives has been proven, the use of animals should not be compromised., (Copyright © 2021 Elsevier Inc. All rights reserved.)
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- 2021
- Full Text
- View/download PDF
8. Sublayer- and cell-type-specific neurodegenerative transcriptional trajectories in hippocampal sclerosis.
- Author
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Cid E, Marquez-Galera A, Valero M, Gal B, Medeiros DC, Navarron CM, Ballesteros-Esteban L, Reig-Viader R, Morales AV, Fernandez-Lamo I, Gomez-Dominguez D, Sato M, Hayashi Y, Bayés À, Barco A, Lopez-Atalaya JP, and de la Prida LM
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- Animals, Humans, Mice, Epilepsy pathology, Hippocampus metabolism, Neurodegenerative Diseases physiopathology, Neurons pathology, Sclerosis genetics
- Abstract
Hippocampal sclerosis, the major neuropathological hallmark of temporal lobe epilepsy, is characterized by different patterns of neuronal loss. The mechanisms of cell-type-specific vulnerability and their progression and histopathological classification remain controversial. Using single-cell electrophysiology in vivo and immediate-early gene expression, we reveal that superficial CA1 pyramidal neurons are overactive in epileptic rodents. Bulk tissue and single-nucleus expression profiling disclose sublayer-specific transcriptomic signatures and robust microglial pro-inflammatory responses. Transcripts regulating neuronal processes such as voltage channels, synaptic signaling, and cell adhesion are deregulated differently by epilepsy across sublayers, whereas neurodegenerative signatures primarily involve superficial cells. Pseudotime analysis of gene expression in single nuclei and in situ validation reveal separated trajectories from health to epilepsy across cell types and identify a subset of superficial cells undergoing a later stage in neurodegeneration. Our findings indicate that sublayer- and cell-type-specific changes associated with selective CA1 neuronal damage contribute to progression of hippocampal sclerosis., Competing Interests: Declaration of interests The authors declare no competing interests., (Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
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