1. Orally Administered Polysaccharide Derived from Blackcurrants (Ribes nigrum L.) Improves Skin Hydration in Ultraviolet-Irradiated Hairless Mice
- Author
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Kazuko Sunaga, Reiko Yamamoto, Yuta Komano, Ryoji Takata, Guanying Wang, Hiroshi Ashigai, Yasuji Kawachi, and Takaaki Yanai
- Subjects
0301 basic medicine ,chemistry.chemical_classification ,Nutrition and Dietetics ,integumentary system ,biology ,Cassis ,Medicine (miscellaneous) ,Inflammation ,Atopic dermatitis ,Pharmacology ,Matrix metalloproteinase ,Polysaccharide ,biology.organism_classification ,medicine.disease ,Hairless ,030207 dermatology & venereal diseases ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,chemistry ,Oral administration ,medicine ,Dehydration ,medicine.symptom - Abstract
Blackcurrants (Ribes nigrum L.) have various benefits for human health. In particular, a polysaccharide derived from blackcurrant was found to be an immunostimulating food ingredient in a mouse model. We named a polysaccharide derived from blackcurrant cassis polysaccharide (CAPS). In a previous clinical study, we reported that CAPS affects skin dehydration, demonstrating its effectiveness against skin inflammation was related to atopic dermatitis; skin inflammation caused skin dehydration. However, there are no studies regarding CAPS effectiveness against skin dehydration. The current study aimed to investigate CAPS effectiveness against skin dehydration. We further demonstrate the effect of oral administration of CAPS on skin dehydration caused by ultraviolet (UV) irradiation-induced inflammation in mice. We found that CAPS administration suppresses skin dehydration caused by UV irradiation. We also found that CAPS decreases interleukin-6 and matrix metalloproteinase transcription levels in the mouse skin. These results show that CAPS improves skin hydration in UV-irradiated mice.
- Published
- 2018
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