1. Pregnancy Outcomes among Women Receiving rVSVΔ-ZEBOV-GP Ebola Vaccine during the Sierra Leone Trial to Introduce a Vaccine against Ebola
- Author
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Rosalind J Carter, Olamide D Jarrett, Elena Szefer, Barbara E. Mahon, Mohamed Samai, Susan T. Goldstein, Sarah C. Tinker, Jennifer Legardy-Williams, and Augustin E Fombah
- Subjects
Pediatrics ,Epidemiology ,viruses ,lcsh:Medicine ,medicine.disease_cause ,Pregnancy Outcomes among Women Receiving rVSVΔ-ZEBOV-GP Ebola Vaccine during the Sierra Leone Trial to Introduce a Vaccine against Ebola ,Ebola virus ,0302 clinical medicine ,Pregnancy ,Medicine ,vaccine safety ,030212 general & internal medicine ,Pregnancy Complications, Infectious ,Uncategorized ,Ebola vaccine ,Vaccination ,Pregnancy Outcome ,virus diseases ,Prenatal Care ,Infectious Diseases ,Ebola ,Vaccine-preventable diseases ,Female ,Microbiology (medical) ,Adult ,medicine.medical_specialty ,Blinding ,030231 tropical medicine ,Ebola virus disease ,Prenatal care ,rVSVΔ-ZEBOV-GP ,Sierra leone ,lcsh:Infectious and parasitic diseases ,Sierra Leone ,03 medical and health sciences ,Young Adult ,Double-Blind Method ,West Africa ,Humans ,lcsh:RC109-216 ,Ebola Vaccines ,Sierra Leone Trial to Introduce a Vaccine against Ebola ,business.industry ,Research ,lcsh:R ,Hemorrhagic Fever, Ebola ,medicine.disease ,STRIVE ,vaccine-preventable diseases ,business - Abstract
Little information exists regarding Ebola vaccine rVSVΔGZEBOV-GP and pregnancy. The Sierra Leone Trial to Introduce a Vaccine against Ebola (STRIVE) randomized participants without blinding to immediate or deferred (18-24 weeks postenrollment) vaccination. Pregnancy was an exclusion criterion, but 84 women were inadvertently vaccinated in early pregnancy or became pregnant 15 days after vaccination) (45% [10/22]). No congenital anomalies were detected among 44 live-born infants examined. These data highlight the need for Ebola vaccination decisions to balance the possible risk for an adverse pregnancy outcome with the risk for Ebola exposure.
- Published
- 2020