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Leukemia is a neoplastic disorder of the blood forming tissues, primarily affecting leukocytes. This is heterogeneous group of diseases, which occurs from a neoplastic proliferation in the bone marrow. The replacement of normal bone marrow elements by leukemic cells causes decreased production of erythrocytes, normal white blood cells and platelets. The clinical result is anemia with weakness, fatigue, pallor of skin and mucosal membranes; thrombocytopenia with associated bleeding tendencies and leucopenia resulting in increased susceptibility to infection. Leukemia is of special interest to the dentists because he is frequently the first person to whom the patient turns for treatment. Dental procedures such as oral surgery, periodontal treatment, or even prophylaxis that produced trauma to the tissue may aggravate the situation and give rise to exacerbations of acute symptoms, which can result in death. Primarily, oral clinical manifestations may be consisting of gingivitis, gingival hyperplasia, hemorrhage, petechiae, erosion ulceration and necrosis of the gingiva and mucosa. The aim of this article is to evaluate the oral signs and symptoms of leukemia and present a clinical case, 59-old female with oral and extra-oral manifestation, as an initial signs of the disease.

The term implantation involves the installation of a dedicated specially designed allogeneic material in live tissu. Oral implantology as an integral part of dentistry, aims to make up for lost teeth, and at the same time to improve the function of chewing, speech and aesthetics. In a certain number of patients with implant there can be certain complications, even complete implant failure at the level of installation. Such complications can arise immediately after implant placement or later, when the implant osseointegration is achieved and put into operation, i.e. in the phase of prosthetic reconstruction, or after setting superstructure.It can be said that the success of the osseointegration of implants is depending on: the biological nature of bone tissue, physical characteristics, construction, building and forces to which it is exposed after its making. After the process it comes clearly that balance is necessary between the force to which an implant and superstructure is subjected on the one hand and the resistance structure, which ensures its support during oral masticatory function, on the other hand.