Density, ρ, viscosity, η, speed of sound, u, and refractive index, nD, were measured for the binary systems of ethyl acetoacetate with dichloromethane, chloroform, carbon tetrachloride, nitromethane, methyl acetate, acetonitrile and acetic acid at 298.15 K over the entire composition range. From the experimental results, the excess molar volume, VE and the deviation in viscosity, Δ η, were calculated. Isentropic compressibility, kSE, and deviation in molar refractive index, Δ R, were also calculated. These results were fitted to Redlich-Kister polynomial equation. The density and viscosity data were analyzed by some semi-empirical viscosity models, and the results have been discussed in terms of molecular interactions and structural effects. The excess properties were found to be either negative or positive depending on the molecular interactions and the nature of liquid mixtures. To explore the nature of the interactions, various thermodynamic parameters (e.g., intermolecular free length, specific acoustic impedance, etc.) have also been derived from the density and ultrasonic speed data.