1. Insulin-like growth factor binding protein-4 inhibits cell growth, migration and invasion, and downregulates COX-2 expression in A549 lung cancer cells.
- Author
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Li W, Sun D, Lv Z, Wei Y, Zheng L, Zeng T, and Zhao J
- Subjects
- A549 Cells, Antineoplastic Agents pharmacology, Cell Proliferation, Down-Regulation, Drug Screening Assays, Antitumor, Humans, Insulin-Like Growth Factor Binding Protein 4 pharmacology, Lipopolysaccharides pharmacology, Lung Neoplasms drug therapy, Lung Neoplasms immunology, Lung Neoplasms metabolism, Lung Neoplasms pathology, Neoplasm Invasiveness, Phosphatidylinositol 3-Kinases metabolism, Phosphorylation, Protein Processing, Post-Translational, Signal Transduction, Cell Movement, Cyclooxygenase 2 metabolism, Insulin-Like Growth Factor Binding Protein 4 physiology
- Abstract
Insulin-like growth factor binding protein 4 (IGFBP-4) and cyclooxygenase2 (COX-2) are associated with tumor inflammatory microenvironment which is involved in the progression of tumor. However, it is unclear that the roles of IGFBP-4 in lung cancer and the effects of IGFBP-4 on COX-2 expression. In this study, we showed that IGFBP-4 could decrease COX-2 production in lung cancer A549 cells. IGFBP-4 expression was significantly lower but COX-2 expression was higher in lung cancer tissues compared to matched adjacent normal tissues. In addition, IGFBP-4 could inhibit lung cancer cell proliferation, migration and invasion, and suppress the phosphorylation of PI3 K/AKT, ERK, and CREB. These results indicate that IGFBP-4 has potent antitumor effects in non-small cell lung cancer cells., (© 2017 International Federation for Cell Biology.) more...
- Published
- 2017
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