1. Research progress in immunology and osteoporosis.
- Author
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WANG Yongfu, CHANG Zhifang, SHI Xiaoxia, and FENG Chenglong
- Abstract
As the aging population increases in China, the incidence of osteoporosis increases as well. Because of the progress in osteoporosis study, the pathogenesis of osteoporosis has increasingly drawn attention in the recent years. In the traditional concept, the cause of osteoporosis includes endocrine disturbance, metabolic disturbance, and mechanical factor. However, the concept of osteoimmunology has been suggested recently. It is considered that immune system and immune factor play an important role in the development of osteoporosis. Osteoimmunology is a field of research dedicating to the study of the interactions between the immune system, the hemopoietic system, and the bone. The cells in the immune system that regulate bone cells and the hemopoietic function are T lymphocytes. These cells secrete inflammatory cytokines and Wnt ligands that promote bone resorption and stimulate bone formation. In addition, T cells regulate bone homeostasis by cross talking with BM stromal cells and osteoblastic cells via CD40 ligand (CD40L) and other costimulatory molecules. This article describes the effect of immune factor on the development of osteoporosis. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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