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BACKGROUND: Tissue engineering technology provides an effective medical means to solve the problems of organ donor insufficiency and tissue trauma reconstruction. OBJECTIVE: To provide information reference for researchers of tissue engineering through the analysis of the patents data to grasp the hotspot and core technologies of tissue engineering. METHODS: The information including the annual distribution of patents, priority countries, patentees, hotspot of technology and core patents by Excel after extracting the data by programming based on Derwent Innovations Index. RESULTS AND CONCLUSION: In the past decade, the number of patents in the field of tissue engineering is on a rise. The most prolific countries are the United States, China and Japan. Zhejiang University, Donghua University, and the University of California are the leading institutions. Two United States companies, TYCO HEALTHCARE GROUP LP and ETHICON INC, each have two of the 20 core patents. The market of the relevant tissue-engineered products is led by the United States. Scaffolds, tissue engineering technology and prosthesis are the hot areas of tissue engineering. Scaffold materials, extracellular matrix, drug delivery, construction technology, and devices are the core technologies in the field of tissue engineering. [ABSTRACT FROM AUTHOR]