1. [A case control study on the impact of CYP450 MSPI and GST-M1 polymorphisms on the risk of lung cancer].
- Author
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Wang BG, Chen SD, Zhou WP, Zeng M, Li ZB, Cai XL, and Wang DQ
- Subjects
- Adult, Aged, Aged, 80 and over, Case-Control Studies, Female, Genotype, Humans, Lung Neoplasms etiology, Male, Middle Aged, Risk, Smoking adverse effects, Cytochrome P-450 CYP1A1 genetics, Glutathione Transferase genetics, Lung Neoplasms genetics, Polymorphism, Genetic
- Abstract
Objective: To study the correlation of polymorphisms of CYP1A1 MSPI and glutathiones S-transferase (GST-M1) independently and in combination with the risk of lung cancer., Methods: A case control study which included 91 cases of lung cancer and 138 controls collected from the First Affiliated Hospital of Sun Yat-sen University of Medical Sciences, Guangzhou Tumor Hospital and The Red Cross Hospital of Guangzhou or conmunity area. All subjects were investigated with a uniform questionnaire. Blood samples were collected from all cases and controls for detecting CYP1A1 MSPI and GST-M1 polymorphisms which were analyzed by PCR and RFLP., Results: It showed that there was no significant difference in frequencies of this genotypes of CYP1A1 MSPI between the two groups. The frequency of GST-M1 null (0/0) genotype was higher in the case group than in the control group, with an OR of 1.38 (95% CI 0.81 - 2.38), but there was no statistical significance. However, combination of several genotypes was strongly associated with lung cancer. There was a synergistic interaction between the m2m2 genotype of CYP1A1 MSPI and GST-M1 (0/0) genotype, with an OR of 2.47 (95% CI 1.03 - 5.90)., Conclusion: The combination of two genetic polymorphisms significantly increases the risk of lung cancer.
- Published
- 2004