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Start Over Author "Han WD" Publisher chinese medical association
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2. [Study on DNA methylation status of WT1 gene promoter in leukemia cell].

Author

Wang QS, Yu L, Zhao Y, Han WD, Gao CJ, and Lou FD

Subjects
Cell Line, Tumor, DNA Methylation, Genes, Wilms Tumor, Humans, Polymerase Chain Reaction, Promoter Regions, Genetic, Leukemia genetics
Abstract

Objective: To analyse the WT1 expression and its DNA methylation status of its promoter domain., Method: The expression of WT1 gene and its DNA methylation status were assayed in leukemia cell lines and normal peripheral blood mononuclear cells (PBMNC) by RT-PCR and MS-PCR., Results: WT1 was overexpressed in HL60, K562 and KG1 leukemia cell lines, but not in U937 and PBMNC. Methylation of WT1 promoter was not observed in HL60 cells., Conclusion: DNA methylation of WT1 gene promotor did not inhibit its expression. Other mechanisms may appear to regulate the WT1 expression.

Published
2003

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