1. White-matter changes in early and late stages of mild cognitive impairment
- Author
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Banu Femir-Gurtuna, Elif Kurt, Ali Bayram, Cigdem Ulasoglu-Yildiz, Elif Yildirim, Ezgi Soncu-Buyukiscan, Başar Bilgiç, Işık Üniversitesi, Fen Edebiyat Fakültesi, Psikoloji Bölümü, Işık University, Faculty of Arts and Sciences, Department of Psychology, and Yıldırım, Elif
- Subjects
Male ,Activities of daily living ,Hippocampus ,Hyperintensities ,Audiology ,Cognition ,0302 clinical medicine ,Cognitive decline ,Episodic memory ,Brain ,General Medicine ,Middle Aged ,Magnetic Resonance Imaging ,White Matter ,Neurology ,030220 oncology & carcinogenesis ,Alzheimers-disease ,Female ,medicine.medical_specialty ,behavioral disciplines and activities ,03 medical and health sciences ,Physiology (medical) ,mental disorders ,medicine ,Humans ,Dementia ,Cognitive Dysfunction ,Effects of sleep deprivation on cognitive performance ,Aged ,business.industry ,Mild cognitive impairment ,Conversion ,medicine.disease ,Hyperintensity ,nervous system diseases ,White-matter hyperintensities ,Dysfunction ,Lesions ,Surgery ,sense organs ,Neurology (clinical) ,Cognition Disorders ,business ,Prediction ,human activities ,030217 neurology & neurosurgery - Abstract
PubMed ID: 32334962 Mild Cognitive Impairment (MCI) is characterized by cognitive deficits that exceed age-related decline, but not interfering with daily living activities. Amnestic type of the disorder (aMCI) is known to have a high risk to progress to Alzheimer's Disease (AD), the most common type of dementia. Identification of very early structural changes in the brain related to the cognitive decline in MCI patients would further contribute to the understanding of the dementias. In the current study, we target to investigate whether the white-matter changes are related to structural changes, as well as the cognitive performance of MCI patients. Forty-nine MCI patients were classified as Early MCI (E-MCI, n = 24) and Late MCI (L-MCI, n = 25) due to their performance on The Free and Cued Selective Reminding Test (FCSRT). Age-Related White-Matter Changes (ARWMC) scale was used to evaluate the white-matter changes in the brain. Volumes of specific brain regions were calculated with the FreeSurfer program. Both group and correlation analyses were conducted to show if there was any association between white-matter hyperintensities (WMHs) and structural changes and cognitive performance. Our results indicate that, L-MCI patients had significantly more WMHs not in all but only in the frontal regions compared to E-MCI patients. Besides, ARWMC scores were not correlated with total hippocampal and white-matter volumes. It can be concluded that WMHs play an important role in MCI and cognitive functions are affected by white-matter changes of MCI patients, especially in the frontal regions. This work was supported by funds from TUBITAK ARDEB 1003 Program (Grant #: 114E053), Istanbul University Scientific Research Funds (Grant #s: 53037, 1567/42362) and Bogazici University Scientific Research Funds (Grant #: 10520) Publisher's Version
- Published
- 2020