1. Both basal and post-prandial muscle protein synthesis rates, following the ingestion of a leucine-enriched whey protein supplement, are not impaired in sarcopenic older males
- Author
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Yvette Luiking, Jörgen Bierau, Imre W. K. Kouw, A.P. Gijsen, Janneau van Kranenburg, Martijn Poeze, Lex B. Verdijk, Henrike M. Hamer, Joan M. G. Senden, Irene Fleur Kramer, Luc J. C. van Loon, Sjors Verlaan, Human Physiology and Sports Physiotherapy Research Group, Physiotherapy, Human Physiology and Anatomy, Promovendi NTM, RS: NUTRIM - R3 - Chronic inflammatory disease and wasting, RS: NUTRIM - R3 - Respiratory & Age-related Health, RS: NUTRIM - HB/BW section A, Ondersteunend personeel NTM, MUMC+: DA KG Lab Centraal Lab (9), MUMC+: MA Heelkunde (9), MUMC+: NAZL en ROAZ (9), Surgery, and RS: NUTRIM - R2 - Gut-liver homeostasis
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0301 basic medicine ,Blood Glucose ,STIMULATION ,Male ,Whey protein ,muscle ,Protein metabolism ,Muscle Proteins ,Critical Care and Intensive Care Medicine ,chemistry.chemical_compound ,Basal (phylogenetics) ,0302 clinical medicine ,Sarcopenia/diet therapy ,Ingestion ,Insulin ,ANABOLIC RESISTANCE ,Muscle Proteins/biosynthesis ,RESISTANCE EXERCISE ,education.field_of_study ,Nutrition and Dietetics ,exercise ,Hand Strength ,digestive, oral, and skin physiology ,Postprandial Period ,medicine.anatomical_structure ,protein metabolism ,Food, Fortified ,ESSENTIAL AMINO-ACIDS ,SKELETAL-MUSCLE ,medicine.medical_specialty ,BED REST ,Phenylalanine ,Population ,ELDERLY-MEN ,030209 endocrinology & metabolism ,Case-control studies ,elderly ,dietary supplements ,sarcopenia ,03 medical and health sciences ,Leucine ,Internal medicine ,Hand strength ,medicine ,Journal Article ,Humans ,education ,Muscle, Skeletal ,KINETICS ,Aged ,030109 nutrition & dietetics ,Muscle, Skeletal/metabolism ,Blood Glucose/metabolism ,business.industry ,Amino Acids, Essential/blood ,Skeletal muscle ,ADULTS ,medicine.disease ,Phenylalanine/blood ,stable isotope methodology ,Endocrinology ,Whey Proteins ,Leucine/administration & dosage ,chemistry ,Sarcopenia ,Protein Biosynthesis ,YOUNG ,Amino Acids, Essential ,Whey Proteins/administration & dosage ,business ,Insulin/blood ,aged, 80 and over ,diet - Abstract
Background: Studying the muscle protein synthetic response to food intake in elderly is important, as it aids the development of interventions to combat sarcopenia. Although sarcopenic elderly are the target group for many of these nutritional interventions, no studies have assessed basal or post-prandial muscle protein synthesis rates in this population.Objective: To assess the basal and post-prandial muscle protein synthesis rates between healthy and sarcopenic older men.Design: A total of 15 healthy (69 +/- 1 y) and 15 sarcopenic (81 +/- 1 y) older men ingested a leucine-enriched whey protein nutritional supplement containing 21 g of protein, 9 g of carbohydrate, and 3 g of fat. Stable isotope methodology combined with frequent collection of blood and muscle samples was applied to assess basal and post-prandial muscle protein fractional synthetic rates. Handgrip strength, muscle mass, and gait speed were assessed to identify sarcopenia, according to international criteria. Results: Basal mixed muscle protein fractional synthetic rates (FSR) averaged 0.040 +/- 0.005 and 0.032 +/- 0.003%/h (mean +/- SEM) in the sarcopenic and healthy group, respectively (P = 0.14). Following protein ingestion, FSR increased significantly to 0.055 +/- 0.004 and 0.053 +/- 0.004%/h in the post-prandial period in the sarcopenic (P = 0.003) and healthy groups (P Conclusions: Basal muscle protein synthesis rates are not lower in sarcopenic older men compared to healthy older men. The ingestion of 21 g of a leucine-enriched whey protein effectively increases muscle protein synthesis rates in both sarcopenic and healthy older men. (C) 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
- Published
- 2016