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the treatment of oral cancer requires different surgical approaches such as marginal or segmental mandibular resection in order to allow a safe removal of the neoplastic lesion. The aim of this work is to evaluate the efficacy of an implant-supported denture rehabilitation for restoring oral function and facial appearance on a hemimandibulectomized patient.the patient was a 64 years old man, hard smoker and moderate drinker. Due to a jaw neoplastic lesion, he underwent a hemimandibulectomy, followed by the insertion of 4 implant fixtures at the chin cap symphysis site. The denture rehabilitation consisted in an over-denture mounted onto a bar furnished by a condylar eminence in articulation with the glenoid fossa of the upper denture.this type of implant-supported denture rehabilitation allows the recovery of the masticatory function and the mandibular reposition with a satisfactory restoration of the proper facial symmetry and appearance.in the edentulous patient implant-supported denture with artificial condyle allows the recovery of the masticatory function without the need of additional operations to re-establish the temporomandibular joint anatomy. It is currently considered as a low invasive technique with very low risk of side effects.

Aim of the study: this study explores the association between cross linked telopetide test (CTX) and individual surgical risk of osteonecrosis in patients taking oral bisphosphonate. Materials and Methods: 32 patients receiving bisphosphonate were treated surgically. Patients were divided into three groups according to type of drug administrated and were subjected to a treatment of oral surgery, such as simple avulsions and reclamation of the oral cavity, upon evaluation of CTX values and antibiotic prophylaxis. Results: within the sample of 32 patients, 12 patients had been treated with bisphosphonates for several years and none developed osteonecrosis of the jaw upon surgery. As for CTX, patients treated with oral bisphosphonates showed a mean value of serum C-telopetides of 0.2869 ng/ml. The mean value of CTX did not differ significantly between patients taking oral bisphosphonates and healthy patients not treated with bisphosphonates. Conclusion: none of the patients subjected to preoperative antibiotic prophylaxis developed osteonecrosis of the jaw after surgery. The pharmacological and surgical protocol tested appeared valid in the prevention of osteonecrosis associated to bisphosphonates