1. Septal GABAergic Inputs to CA1 Govern Contextual Memory Retrieval
- Author
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Srinidhi Desikan, Arnau Sans-Dublanc, Jaime de la Rocha, Marta Pascual, Adria Razzauti, Hannah Monyer, and Carlos Sindreu
- Subjects
MAPK/ERK pathway ,0303 health sciences ,Blocking (radio) ,Ca1 pyramidal neuron ,musculoskeletal, neural, and ocular physiology ,Contextual fear ,03 medical and health sciences ,0302 clinical medicine ,Kinase signaling ,nervous system ,GABAergic ,Psychology ,Contextual memory ,Episodic memory ,Neuroscience ,030217 neurology & neurosurgery ,030304 developmental biology - Abstract
Whether projections from the medial septum regulate the function of the CA1 hippocampus in episodic memory retrieval is not known. Here we show that septal GABAergic inputs to CA1 promote contextual fear memory, blocking the activation of parvalbumin-rich interneurons to facilitate Erk/MAP-kinase signaling in pyramidal cells during retrieval. Thus, suppression of feed-forward inhibition onto CA1 by septal GABAergic neurons gates contextual fear behavior.
- Published
- 2019
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