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Start Over Author "Chris Bauer" Publisher cold spring harbor laboratory
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1. A novel approach reveals that HLA class 1 single antigen bead-signatures provide a means of high-accuracy pre-transplant risk assessment of acute cellular rejection

Author

Nicole Wittenbrink, Sabrina Herrmann, Arturo Blazquez-Navarro, Alessandro Gulberti, Chris Bauer, Eric Lindberg, Petra Reinke, Birgit Sawitzki, Oliver Thomusch, Christian Hugo, Nina Babel, Harald Seitz, and Michal Or-Guil

Subjects
Oncology, medicine.medical_specialty, biology, business.industry, Acute cellular rejection, Human leukocyte antigen, medicine.disease, Complement-dependent cytotoxicity, Antigen, Internal medicine, medicine, biology.protein, Antibody, Single antigen bead, Risk assessment, business, Kidney transplantation
Abstract

SummaryAcute cellular rejection (ACR) is associated with complications after kidney transplantation, such as graft dysfunction and graft loss. Early risk assessment is therefore critical for the improvement of transplantation outcomes. In this work, we retrospectively analyzed a pre-transplant HLA antigen bead assay data set that was acquired by the e:KID consortium as part of a systems medicine approach. The data set included single antigen bead (SAB) reactivity profiles of 52 low-risk graft recipients (negative complement dependent cytotoxicity crossmatch, PRA

Published
2018
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