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Your search keyword '"Crickx, Etienne"' showing total 10 results
Start Over Author "Crickx, Etienne" Publisher cold spring harbor laboratory
10 results on '"Crickx, Etienne"'

1. Single-cell RNA-sequencing of PBMCs from SAVI patients reveals disease-associated monocytes with elevated integrated stress response

Author

de Cevins, Camille, primary, Delage, Laure, additional, Batignes, Maxime, additional, Riller, Quentin, additional, Luka, Marine, additional, Remaury, Anne, additional, Sorin, Boris, additional, Fali, Tinhinane, additional, Masson, Cecile, additional, Hoareau, Benedicte, additional, Meunier, Catherine, additional, Parisot, Melanie, additional, Zarhrate, Mohammed, additional, Perot, Brieuc Pierre, additional, Garcia, Victor, additional, Carbone, Francesco, additional, Canard, Luc, additional, Boussard, Charlotte, additional, Crickx, Etienne, additional, Guillemot, Jean-Claude, additional, Fremont, Marie-Louise, additional, Neven, Benedicte, additional, Boldina, Galina, additional, Auge, Franck, additional, Fischer, Alain, additional, Dider, Michel, additional, Rieux-Laucat, Frederic, additional, and Menager, Mickael Mathieu, additional

Published
2023
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2. Omicron BA.1 breakthrough infection drives long-term remodeling of the memory B cell repertoire in vaccinated individuals

Author

Sokal, Aurélien, Barba-Spaeth, Giovanna, Hunault, Lise, Fernández, Ignacio, Broketa, Matteo, Meola, Annalisa, Fourati, Slim, Azzaoui, Imane, Vandenberghe, Alexis, Lagouge-Roussey, Pauline, Broutin, Manon, Roeser, Anais, Bouvier-Alias, Magali, Crickx, Etienne, Languille, Laetitia, Fournier, Morgane, Michel, Marc, Godeau, Bertrand, Gallien, Sébastien, Melica, Giovanna, Nguyen, Yann, Canoui-Poitrine, Florence, Noizat-Pirenne, France, Megret, Jérôme, Pawlotsky, Jean-Michel, Fillatreau, Simon, Reynaud, Claude-Agnès, Weill, Jean-Claude, Rey, Félix, Bruhns, Pierre, Mahévas, Matthieu, Chappert, Pascal, Institut Necker Enfants-Malades (INEM - UM 111 (UMR 8253 / U1151)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CIC - CHU Henri Mondor, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Virologie Structurale - Structural Virology, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Anticorps en thérapie et pathologie - Antibodies in Therapy and Pathology, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Physiologie, physiopathologie et thérapeutique (ED 394), Sorbonne Université (SU), Centre d'Immunologie et des Maladies Infectieuses (CIMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), CHU Henri Mondor [Créteil], Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Hôpital Henri Mondor, Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Hôpital Cochin [AP-HP], IMRB - CEPIA/'Clinical Epidemiology And Ageing : Geriatrics, Primary Care and Public Health' [Créteil] (U955 Inserm - UPEC), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Etablissement Français du Sang [Créteil], Structure Fédérative de Recherche Necker (SFR Necker - UMS 3633 / US24), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), and This work was funded by the CAPNET (Comité ad-hoc de pilotage national des essaisthérapeutiques et autres recherches, French government) and by the Fondation PrincesseGrace. Assistance Publique – Hôpitaux de Paris (AP-HP, Département de la Recherche Cli-nique et du Développement) was the promotor and sponsor of MEMO-COV-2. Work in theUnit of Structural Virology was funded by Institut Pasteur, Urgence COVID-19 FundraisingCampaign of Institut Pasteur. PB acknowledges funding from the Institut Pasteur and InsitutNational de la Santé et de la Recherche Médicale (INSERM). AS was supported by a Posted’accueil from INSERM.

Subjects
[SDV]Life Sciences [q-bio], [SDV.IMM]Life Sciences [q-bio]/Immunology
Abstract

SummaryHow infection by a viral variant showing antigenic drift impacts a preformed mature human memory B cell (MBC) repertoire remains an open question. Here, we studied the MBC response up to 6 months after Omicron BA.1 breakthrough infection in individuals previously vaccinated with three doses of mRNA vaccine. Longitudinal analysis, using single-cell multi-omics and functional analysis of monoclonal antibodies from RBD-specific MBCs, revealed that a BA.1 breakthrough infection mostly recruited pre-existing cross-reactive MBCs with limitedde novoresponse against BA.1-restricted epitopes. Reorganization of clonal hierarchy and new rounds of germinal center reaction, however, combined to maintain diversity and induce progressive maturation of the MBC repertoire against common Hu-1 and BA.1, but not BA.5-restricted, SARS-CoV-2 Spike RBD epitopes. Such remodeling was further associated with marked improvement in overall neutralizing breadth and potency. These findings have fundamental implications for the design of future vaccination booster strategies.

Published
2023
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3. Omicron BA.1 breakthrough infection drives long-term remodeling of the memory B cell repertoire in vaccinated individuals

Author

Sokal, Aurélien, primary, Barba-Spaeth, Giovanna, additional, Hunault, Lise, additional, Fernández, Ignacio, additional, Broketa, Matteo, additional, Meola, Annalisa, additional, Fourati, Slim, additional, Azzaoui, Imane, additional, Vandenberghe, Alexis, additional, Lagouge-Roussey, Pauline, additional, Broutin, Manon, additional, Roeser, Anais, additional, Bouvier-Alias, Magali, additional, Crickx, Etienne, additional, Languille, Laetitia, additional, Fournier, Morgane, additional, Michel, Marc, additional, Godeau, Bertrand, additional, Gallien, Sébastien, additional, Melica, Giovanna, additional, Nguyen, Yann, additional, Canoui-Poitrine, Florence, additional, Noizat-Pirenne, France, additional, Megret, Jérôme, additional, Pawlotsky, Jean-Michel, additional, Fillatreau, Simon, additional, Reynaud, Claude-Agnès, additional, Weill, Jean-Claude, additional, Rey, Félix A., additional, Bruhns, Pierre, additional, Mahévas, Matthieu, additional, and Chappert, Pascal, additional

Published
2023
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4. Immune escape of SARS-CoV-2 Omicron variant from mRNA vaccination-elicited RBD-specific memory B cells.

Author

Sokal, Aurelien, primary, Broketa, Matteo, additional, Meola, Annalisa, additional, Barba-Spaeth, Giovanna, additional, Fernandez, Ignacio, additional, Fourati, Slim, additional, Azzaoui, Imane, additional, de La Selle, Andrea, additional, Vandenberghe, Alexis, additional, Roeser, Anais, additional, Bouvier-Alias, Magali, additional, Crickx, Etienne, additional, Languille, Laetitia, additional, Michel, Marc, additional, Godeau, Bertrand, additional, Gallien, Sebastien, additional, Melica, Giovanna, additional, Nguyen, Yann, additional, Zarrouk, Virginie, additional, Canoui-Poitrine, Florence, additional, Noizat-Pirenne, France, additional, Megret, Jerome, additional, Pawlotsky, Jean-Michel, additional, Fillatreau, Simon, additional, Simon-Loriere, Etienne, additional, Weill, Jean-Claude, additional, Reynaud, Claude-Agnes, additional, Rey, Felix A., additional, Bruhns, Pierre, additional, Chappert, Pascal, additional, and Mahevas, Matthieu, additional

Published
2021
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5. No evidence of clinical efficacy of hydroxychloroquine in patients hospitalized for COVID-19 infection with oxygen requirement: results of a study using routinely collected data to emulate a target trial

Author

Mahevas, Matthieu, Tran, Viet-Thi, Roumier, Mathilde, Chabrol, Amelie, Paule, Romain, Guillaud, Constance, Gallien, Sebastien, Lepeule, Raphael, Szwebel, Tali-Anne, Lescure, Xavier, Schlemmer, Frederic, Matignon, Marie, Khellaf, Mehdi, Crickx, Etienne, Terrier, Benjamin, Morbieu, Caroline, Legendre, Paul, Dang, Julien, Schoindre, Yoland, Pawlotski, Jean-Michel, Michel, Marc, Perrodeau, Elodie, Carlier, Nicolas, Roche, Nicolas, De Lastours, Victoire, Mouthon, Luc, Audureau, Etienne, Ravaud, Philippe, Godeau, Bertrand, and Costedoat, Nathalie

Abstract

Background Treatments are urgently needed to prevent respiratory failure and deaths from coronavirus disease 2019 (COVID-19). Hydroxychloroquine (HCQ) has received worldwide attention because of positive results from small studies. Methods We used data collected from routine care of all adults in 4 French hospitals with documented SARS-CoV-2 pneumonia and requiring oxygen ≥ 2 L/min to emulate a target trial aimed at assessing the effectiveness of HCQ at 600 mg/day. The composite primary endpoint was transfer to intensive care unit (ICU) within 7 days from inclusion and/or death from any cause. Analyses were adjusted for confounding factors by inverse probability of treatment weighting. Results This study included 181 patients with SARS-CoV-2 pneumonia; 84 received HCQ within 48 hours of admission (HCQ group) and 97 did not (no-HCQ group). Initial severity was well balanced between the groups. In the weighted analysis, 20.2% patients in the HCQ group were transferred to the ICU or died within 7 days vs 22.1% in the no-HCQ group (16 vs 21 events, relative risk [RR] 0.91, 95% CI 0.47-1.80). In the HCQ group, 2.8% of the patients died within 7 days vs 4.6% in the no-HCQ group (3 vs 4 events, RR 0.61, 95% CI 0.13-2.89), and 27.4% and 24.1%, respectively, developed acute respiratory distress syndrome within 7 days (24 vs 23 events, RR 1.14, 95% CI 0.65-2.00). Eight patients receiving HCQ (9.5%) experienced electrocardiogram modifications requiring HCQ discontinuation. Interpretation These results do not support the use of HCQ in patients hospitalised for documented SARS-CoV-2-positive hypoxic pneumonia.

Published
2020
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6. Single-cell analyses of immune thrombocytopenic patients reveal multiorgan dissemination of high-affinity autoreactive plasma cells

Author

Canales-Herrerias, Pablo, primary, Crickx, Etienne, additional, Broketa, Matteo, additional, Sokal, Aurélien, additional, Chenon, Guilhem, additional, Azzaoui, Imane, additional, Vandenberghe, Alexis, additional, Perima, Angga, additional, Iannascoli, Bruno, additional, Goff, Odile Richard-Le, additional, Castrillon, Carlos, additional, Mottet, Guillaume, additional, Sterlin, Delphine, additional, Robbins, Ailsa, additional, Michel, Marc, additional, England, Patrick, additional, Millot, Gael A., additional, Eyer, Klaus, additional, Baudry, Jean, additional, Mahevas, Matthieu, additional, and Bruhns, Pierre, additional

Published
2021
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7. Memory B cells control SARS-CoV-2 variants upon mRNA vaccination of naive and COVID-19 recovered individuals

Author

Sokal, Aurélien, primary, Barba-Spaeth, Giovanna, additional, Fernández, Ignacio, additional, Broketa, Matteo, additional, Azzaoui, Imane, additional, La Selle, Andrea de, additional, Vandenberghe, Alexis, additional, Fourati, Slim, additional, Roeser, Anais, additional, Meola, Annalisa, additional, Bouvier-Alias, Magali, additional, Crickx, Etienne, additional, Languille, Laetitia, additional, Michel, Marc, additional, Godeau, Bertrand, additional, Gallien, Sébastien, additional, Melica, Giovanna, additional, Nguyen, Yann, additional, Zarrouk, Virginie, additional, Canoui-Poitrine, Florence, additional, Noizat-Pirenne, France, additional, Megret, Jérôme, additional, Pawlotsky, Jean-Michel, additional, Fillatreau, Simon, additional, Bruhns, Pierre, additional, Rey, Felix A., additional, Weill, Jean-Claude, additional, Reynaud, Claude-Agnès, additional, Chappert, Pascal, additional, and Mahévas, Matthieu, additional

Published
2021
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8. Maturation and persistence of the anti-SARS-CoV-2 memory B cell response

Author

Sokal, Aurélien, primary, Chappert, Pascal, additional, Roeser, Anais, additional, Barba-Spaeth, Giovanna, additional, Fourati, Slim, additional, Azzaoui, Imane, additional, Vandenberghe, Alexis, additional, Fernandez, Ignacio, additional, Bouvier-Alias, Magali, additional, Crickx, Etienne, additional, Ferchiou, Asma Beldi, additional, Hue, Sophie, additional, Languille, Laetitia, additional, Baloul, Samia, additional, Noizat-Pirenne, France, additional, Luka, Marine, additional, Megret, Jérôme, additional, Ménager, Mickaël, additional, Pawlotsky, Jean-Michel, additional, Fillatreau, Simon, additional, Rey, Felix A, additional, Weill, Jean-Claude, additional, Reynaud, Claude-Agnès, additional, and Mahévas, Matthieu, additional

Published
2020
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9. No evidence of clinical efficacy of hydroxychloroquine in patients hospitalised for COVID-19 infection and requiring oxygen: results of a study using routinely collected data to emulate a target trial

Author

Mahévas, Matthieu, primary, Tran, Viet-Thi, additional, Roumier, Mathilde, additional, Chabrol, Amélie, additional, Paule, Romain, additional, Guillaud, Constance, additional, Gallien, Sébastien, additional, Lepeule, Raphael, additional, Szwebel, Tali-Anne, additional, Lescure, Xavier, additional, Schlemmer, Frédéric, additional, Matignon, Marie, additional, Khellaf, Medhi, additional, Crickx, Etienne, additional, Terrier, Benjamin, additional, Morbieu, Caroline, additional, Legendre, Paul, additional, Dang, Julien, additional, Schoindre, Yoland, additional, Pawlotski, Jean-Michel, additional, Michel, Marc, additional, Perrodeau, Elodie, additional, Carlier, Nicolas, additional, Roche, Nicolas, additional, de Lastours, Victoire, additional, Mouthon, Luc, additional, Audureau, Etienne, additional, Ravaud, Philippe, additional, Godeau, Bertrand, additional, and Costedoat-Chalumeau, Nathalie, additional

Published
2020
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10. A reservoir of rituximab-resistant splenic memory B cells contributes to relapses after B-cell depletion therapy

Author

Crickx, Etienne, primary, Chappert, Pascal, additional, Weller, Sandra, additional, Sokal, Aurélien, additional, Azzaoui, Imane, additional, Vandenberghe, Alexis, additional, Bonnard, Guillaume, additional, Rossi, Geoffrey, additional, Fadeev, Tatiana, additional, Storck, Sébastien, additional, Galicier, Lionel, additional, Meignin, Véronique, additional, Rivière, Etienne, additional, Godeau, Bertrand, additional, Michel, Marc, additional, Weill, Jean-Claude, additional, Reynaud, Claude-Agnès, additional, and Mahévas, Matthieu, additional

Published
2019
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