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Your search keyword '"Curran, Sean"' showing total 11 results
Start Over Author "Curran, Sean" Publisher cold spring harbor laboratory
11 results on '"Curran, Sean"'

7. Ether Lipid Biosynthesis Promotes Lifespan Extension and Enables Diverse Prolongevity Paradigms

Author

Cedillo, Lucydalila, primary, Li, Sainan, additional, Ahsan, Fasih, additional, Stuhr, Nicole L., additional, Zhou, Yifei, additional, Zhang, Yuyao, additional, Adedoja, Adebanjo, additional, Murphy, Luke M., additional, Yerevanian, Armen, additional, Emans, Sinclair, additional, Dao, Khoi, additional, Li, Zhaozhi, additional, Peterson, Nicholas D., additional, Watrous, Jeramie, additional, Jain, Mohit, additional, Das, Sudeshna, additional, Pukkila-Worley, Read, additional, Curran, Sean P., additional, and Soukas, Alexander A., additional

Published
2021
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8. Novel diets as nutraceuticals to alter lifespan and healthspan trajectories in C. elegans

Author

Stuhr, Nicole L. and Curran, Sean P.

Abstract

Diet is one of the more variable aspects in life due to the variety of options that organisms are exposed to in their natural habitats. In the laboratory, C. elegans are raised on bacterial monocultures, traditionally the E.coli B strain OP50, and spontaneously occurring microbial contaminants are removed to limit experimental variability because diet – including the presence of contaminants, can exert a potent influence over animal physiology. In order to diversify the menu available to culture C. elegans in the lab, we have isolated and cultured three such microbes: Methylobacterium, Xanthomonas , and Sphingomonas. The nutritional composition of these diets is unique, and when fed to C. elegans , can differentially alter multiple life history traits including development, reproduction, and metabolism. In light of the influence each diet has on specific physiological attributes, we comprehensively assessed the impact of these diets on animal health and devised a blueprint for utilizing different diet combinations over the lifespan, as a nutraceutical for optimal longevity. The expansion of the bacterial diet options to use in the laboratory will provide a critical tool to better understand the complexities of gene-diet interactions for health.

Published
2020
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