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Your search keyword '"Ghosheh, Yanal"' showing total 5 results
Start Over Author "Ghosheh, Yanal" Publisher cold spring harbor laboratory
5 results on '"Ghosheh, Yanal"'

1. Sex differences in coronary artery disease and diabetes revealed by scRNA-Seq and CITE-Seq of human CD4+ T cells

Author

Saigusa, Ryosuke, primary, Vallejo, Jenifer, additional, Gulati, Rishab, additional, Suthahar, Sujit Silas Armstrong, additional, Suryawanshi, Vasantika, additional, Alimadadi, Ahmad, additional, Markings, Jeff, additional, Durant, Christopher P., additional, Freuchet, Antoine, additional, Roy, Payel, additional, Ghosheh, Yanal, additional, Pandori, William, additional, Pattarabanjird, Tanyaporn, additional, Drago, Fabrizio, additional, McNamara, Coleen A., additional, Shemesh, Avishai, additional, Lanier, Lewis L., additional, Hedrick, Catherine C., additional, and Ley, Klaus, additional

Published
2022
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3. Combined protein and transcript single cell RNA sequencing in human peripheral blood mononuclear cells

Author

Vallejo, Jenifer, primary, Saigusa, Ryosuke, additional, Gulati, Rishab, additional, Ghosheh, Yanal, additional, Durant, Christopher P., additional, Roy, Payel, additional, Ehinger, Erik, additional, Suryawanshi, Vasantika, additional, Pattarabanjird, Tanyaporn, additional, Padgett, Lindsey E., additional, Olingy, Claire E., additional, Hanna, David B., additional, Landay, Alan L., additional, Tracy, Russell P., additional, Lazar, Jason M., additional, Mack, Wendy J., additional, Weber, Kathleen M., additional, Adimora, Adaora A., additional, Hodis, Howard N., additional, Tien, Phyllis C., additional, Ofotokun, Igho, additional, Heath, Sonya L., additional, Blanco-Dominguez, Rafael, additional, Dinh, Huy Q., additional, Shemesh, Avishai, additional, McNamara, Coleen A., additional, Lanier, Lewis L., additional, Hedrick, Catherine C., additional, Kaplan, Robert C., additional, and Ley, Klaus, additional

Published
2020
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4. AGO1 in association with NEAT1 lncRNA contributes to nuclear and 3D chromatin architecture in human cells: Supplemental Data

Author

Shuaib, Muhammad, Parsi, Krishna Mohan, Kawaji, Hideya, Thimma, Manjula, Adroub, Sabir Abdu, Fort, Alexandre, Ghosheh, Yanal, Yamazaki, Tomohiro, Mannen, Taro, Seridi, Loqmane, Fallatah, Bodor, Albawardi, Waad, Ravasi, Timothy, Carninci, Piero, Hirose, Tetsuro, and Orlando, Valerio

Subjects
fungi
Abstract

Aside from their roles in the cytoplasm, RNA-interference components have been reported to localize also in the nucleus of human cells. In particular, AGO1 associates with active chromatin and appears to influence global gene expression. However, the mechanistic aspects remain elusive. Here, we identify AGO1 as a paraspeckle component that in combination with the NEAT1 lncRNA maintains 3D genome architecture. We demonstrate that AGO1 interacts with NEAT1 lncRNA and its depletion affects NEAT1 expression and the formation of paraspeckles. By Hi-C analysis in AGO1 knockdown cells, we observed global changes in chromatin organization, including TADs configuration, and A/B compartment mixing. Consistently, distinct groups of genes located within the differential interacting loci showed altered expression upon AGO1 depletion. NEAT1 knockout cells displayed similar changes in TADs and higher-order A/B compartmentalization. We propose that AGO1 in association with NEAT1 lncRNA can act as a scaffold that bridges chromatin and nuclear bodies to regulate genome organization and gene expression in human cells.

Published
2019
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5. AGO1 in association with NEAT1 lncRNA contributes to nuclear and 3D chromatin architecture in human cells

Author

Shuaib, Muhammad, primary, Parsi, Krishna Mohan, additional, Kawaji, Hideya, additional, Thimma, Manjula, additional, Adroub, Sabir Abdu, additional, Fort, Alexandre, additional, Ghosheh, Yanal, additional, Yamazaki, Tomohiro, additional, Mannen, Taro, additional, Seridi, Loqmane, additional, Fallatah, Bodor, additional, Albawardi, Waad, additional, Ravasi, Timothy, additional, Carninci, Piero, additional, Hirose, Tetsuro, additional, and Orlando, Valerio, additional

Published
2019
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