1. Genetic variation and sex differences are missed opportunities for addiction biology
- Author
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Saul, Michael C., Bagley, Jared R., Bailey, Lauren S., Datta, Udita, Dickson, Price E., Dodd, Rainy, Gagnon, Leona H., Kimble, Violet M., Leonardo, Michael, Kim, Sam-Moon, Olson, Ashley, Roy, Tyler, Schoenrock, Sarah A., Wilcox, Troy, Jentsch, J. David, Logan, Ryan W., McClung, Colleen A., Philip, Vivek M., Reinholdt, Laura G., Sukoff Rizzo, Stacey J., Tarantino, Lisa M., and Chesler, Elissa J.
- Abstract
Though risk for cocaine use disorder is subject to substantial inter-individual variation, the sources of that variation – including, genetics and sex – are too often ignored in studies of this phenomenon. In genetically diverse laboratory mice, these individual differences explain the majority of variance in important cocaine-related behavioral, physiological, and striatum transcriptional responses traits. This individual variation represents a missed opportunity for discovery and translation of addiction mechanisms.
- Published
- 2020
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