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Your search keyword '"Sabrina Coqueran"' showing total 2 results
Start Over Author "Sabrina Coqueran" Publisher cold spring harbor laboratory
2 results on '"Sabrina Coqueran"'

1. Excessive self-grooming, gene dysregulation and imbalance between the striosome and matrix compartments in the striatum ofShank3mutant mice

Author

Allain-Thibeault, Ferhat, primary, Elisabeth, Verpy, additional, Anne, Biton, additional, Benoît, Forget, additional, de Chaumont, Fabrice, additional, Florian, Mueller, additional, Anne-Marie, Le Sourd, additional, Sabrina, Coqueran, additional, Julien, Schmitt, additional, Christelle, Rochefort, additional, Laure, Rondi-Reig, additional, Aziliz, Leboucher, additional, Anne, Boland, additional, Bertrand, Fin, additional, François, Deleuze Jean, additional, Boeckers, Tobias M., additional, Elodie, Ey, additional, and Thomas, Bourgeron, additional

Published
2022
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2. ICM conversion to epiblast by FGF/ERK inhibition is limited in time and requires transcription and protein degradation

Author

Sabrina Coqueran, Jérôme Artus, Sylvain Bessonnard, Sandrine Vandormael-Pournin, Alexandre Dufour, Michel Cohen-Tannoudji, Génétique fonctionnelle de la Souris, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Analyse d'images biologiques - Biological Image Analysis (BIA), Université Paris-Sud - Paris 11 - Faculté de médecine (UP11 UFR Médecine), Université Paris-Sud - Paris 11 (UP11), This work was supported by the Institut Pasteur, the Centre National de la Recherche Scientifique and the Agence Nationale de la Recherche (ANR-10-LABX-73-01 REVIVE and ANR-14CE11-0017 PrEpiSpec). S.B. was supported by the Fondation pour la Recherche Médicale (ARF20150934222). J.A. was supported by the European program Marie Curie (International Incoming Fellowship, Seventh European Community Framework Programme)., Imaging was performed for most parts at the Imagopole of Institut., ANR-10-LABX-0073,REVIVE,Stem Cells in Regenerative Biology and Medicine(2010), ANR-14-CE11-0017,Prepispec,Mécanismes moléculaires de la spécification des lignages cellulaires pendant l'embryogenèse précoce de la souris(2014), European Project: 291784,EC:FP7:PEOPLE,FP7-PEOPLE-2011-COFUND,ZIF-MARIE-CURIE(2012), and Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)

Subjects
MAPK/ERK pathway, Time Factors, Transcription, Genetic, MAP Kinase Signaling System, Cell Plasticity, lcsh:Medicine, Biology, Protein degradation, Fibroblast growth factor, Bioinformatics, Article, Mice, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, Animals, Inner cell mass, Progenitor cell, lcsh:Science, [SDV.BDD]Life Sciences [q-bio]/Development Biology, reproductive and urinary physiology, 030304 developmental biology, 0303 health sciences, lcsh:R, Cell Differentiation, Cell biology, Fibroblast Growth Factors, Epiblast, Blastocyst Inner Cell Mass, Proteolysis, embryonic structures, lcsh:Q, Developmental biology, Germ Layers, 030217 neurology & neurosurgery
Abstract

International audience; Inner cell Mass (ICM) specification into epiblast (Epi) and primitive endoderm (PrE) is an asynchronous and progressive process taking place between E3.0 to E3.75 under the control of the Fibroblast Growth Factor (FGF)/Extracellular signal-Regulated Kinase (ERK) signaling pathway. Here, we have analyzed in details the kinetics of specification and found that ICM cell responsiveness to the up and down regulation of FGF signaling activity are temporally distinct. We also showed that PrE progenitors are generated later than Epi progenitors. We further demonstrated that, during this late phase of specification, a 4 hours period of FGF/ERK inhibition prior E3.75 is sufficient to convert ICM cells into Epi. Finally, we showed that ICM conversion into Epi in response to inhibition during this short time window requires both transcription and proteasome degradation. Collectively, our data give new insights into the timing and mechanisms involved in the process of ICM specification.

Published
2017

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