1. Interplay between the Genetics of Personality Traits, severe Psychiatric Disorders, and COVID-19 Host Genetics in the Susceptibility to SARS-CoV-2 Infection
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Kristina Adorjan, Urs Heilbronner, Marcella Rietschel, Jens Reimer, Detlef E. Dietrich, Heike Anderson-Schmidt, Max Schmauss, Fabian Streit, Monika Budde, Markus Jäger, Chi-Hua Chen, Daniela Reich-Erkelenz, Sabrina K. Schaupp, Janos Kalman, Jerome C. Foo, Bernhardt T. Baune, Markus M. Nöthen, Katrin Gade, Farahnaz Klöhn-Saghatolislam, Eric Poisel, Franziska Degenhardt, Andreas J. Forstner, Volker Arolt, Sergi Papiol, Ashley L. Comes, Carsten Spitzer, Mojtaba Oraki Kohshour, Til Stürmer, Maria Heilbronner, Stephanie H. Witt, Thomas G. Schulze, Manfred Amelang, Stefanie Heilmann-Heimbach, Ole A. Andreassen, Thomas J. Vogl, Carsten Konrad, Eva C. Schulte, Peter Falkai, Andreas J. Fallgatter, Georg Juckel, Jörg Zimmermann, Adrian Loerbroks, Martin von Hagen, Jens Wiltfang, Udo Dannlowski, Fanny Senner, Ion-George Anghelescu, Eva Z. Reininghaus, Fabian U. Lang, Till F. M. Andlauer, and Christian Figge more...
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0303 health sciences ,medicine.medical_specialty ,Linkage disequilibrium ,Extraversion and introversion ,Genome-wide association study ,Biology ,Mental health ,Genetic correlation ,Correlation ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Big Five personality traits ,Psychiatry ,030217 neurology & neurosurgery ,030304 developmental biology ,Genetic association - Abstract
BackgroundThe SARS-CoV-2 pandemic, with all its impacts on our way of life, is affecting our experiences and mental health. Notably, individuals with mental disorders have been reported to have a higher risk of contracting SARS-CoV-2. Personality traits could represent an important determinant of preventative health behavior and, therefore, the risk of contracting the virus.AimsWe examined overlapping genetic underpinnings between major psychiatric disorders, personality traits, and susceptibility to SARS-CoV-2 infection.MethodsLinkage disequilibrium score regression was used to explore the genetic correlations of COVID-19 susceptibility with psychiatric disorders and personality traits based on data from the largest available respective genome-wide association studies (GWAS). In two cohorts (the PsyCourse (n=1346) and the HeiDE (n=3266) study), polygenic risk scores were used to analyze if a genetic association between, psychiatric disorders, personality traits, and COVID-19 susceptibility exists in individual-level data.ResultsWe observed no significant genetic correlations of COVID-19 susceptibility with psychiatric disorders. For personality traits, there was a significant genetic correlation for COVID-19 susceptibility with extraversion (p=1.47×10-5; rg=0.284). Yet, this was not reflected in individual-level data from the PsyCourse and HeiDE studies.ConclusionsWe identified no significant correlation between genetic risk factors for severe psychiatric disorders and genetic risk for COVID-19 susceptibility. Among the personality traits, extraversion showed evidence for a positive genetic association with COVID-19 susceptibility, in one but not in another setting. Overall, these findings highlight a complex contribution of genetic and non-genetic components in the interaction between COVID-19 susceptibility and personality traits or mental disorders. more...
- Published
- 2021
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