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Your search keyword '"Sandor, Cynthia"' showing total 8 results
Start Over Author "Sandor, Cynthia" Publisher cold spring harbor laboratory
8 results on '"Sandor, Cynthia"'

4. A human single-cell atlas of the Substantia nigra reveals novel cell-specific pathways associated with the genetic risk of Parkinson’s disease and neuropsychiatric disorders

Author

Agarwal, Devika, primary, Sandor, Cynthia, additional, Volpato, Viola, additional, Caffrey, Tara, additional, Monzon-Sandoval, Jimena, additional, Bowden, Rory, additional, Alegre-Abarrategui, Javier, additional, Wade-Martins, Richard, additional, and Webber, Caleb, additional

Published
2020
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5. Universal continuous severity traits underlying hundreds of Parkinson’s disease clinical features

Author

Sandor, Cynthia, Millin, Stephanie, Dahl, Andrew, Lawton, Michael, Hubbard, Leon, Bojovic, Bobby, Peyret-Guzzon, Marine, Matten, Hannah, Blancher, Christine, Williams, Nigel, Ben-Shlomo, Yoav, Hu, Michele T., Grosset, Donald G., Marchini, Jonathan, and Webber, Caleb

Abstract

The generation of deeply phenotyped patient cohorts offers an enormous potential to identify disease subtypes with prognostic and therapeutic utility. Here, we quantify diverse Parkinson’s disease patient phenotypes on continuous scales by identifying the underlying axes of phenotypic variation using a Bayesian multiple phenotype mixed model that incorporates genotypic relationships. This approach overcomes many of the limitations associated with clustering methods and better reflects the more continuous phenotypic variation observed amongst patients. We identify three principal axes of Parkinson’s disease patient phenotypic variation which are reproducibly found across three independent, deeply and diversely phenotyped UK and US Parkinson’s disease cohorts. These three axes explain over 75% of the observed clinical variation and remain robustly captured with a fraction of the clinically-recorded features. Using these axes as quantitative traits, we identify significant overlaps in the genetic risk associated with each axis and other human complex diseases, namely coronary artery disease and schizophrenia, providing new avenues for disease-modifying therapies. Our study demonstrates how deeply phenotyped cohorts can be used to identify latent heritable disease-modifying traits.

Published
2019
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6. Universal latent axes capturing Parkinson’s patient deep phenotypic variation reveals patients with a high genetic risk for Alzheimer’s disease are more likely to develop a more aggressive form of Parkinson’s

Author

Sandor, Cynthia, primary, Millin, Stephanie, additional, Dahl, Andrew, additional, Lawton, Michael, additional, Hubbard, Leon, additional, Bojovic, Bobby, additional, Peyret-Guzzon, Marine, additional, Matten, Hannah, additional, Blancher, Christine, additional, Williams, Nigel, additional, Ben-Shlomo, Yoav, additional, Hu, Michele T., additional, Grosset, Donald G., additional, Marchini, Jonathan, additional, and Webber, Caleb, additional

Published
2019
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7. The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function

Author

Ward, Joey, primary, Tunbridge, Elizabeth M., additional, Sandor, Cynthia, additional, Lyall, Laura M., additional, Ferguson, Amy, additional, Strawbridge, Rona J., additional, Lyall, Donald M., additional, Cullen, Breda, additional, Graham, Nicholas, additional, Johnston, Keira J.A., additional, Webber, Caleb, additional, Escott-Price, Valentina, additional, ODonovan, Michael, additional, Pell, Jill P., additional, Bailey, Mark E.S., additional, Harrison, Paul J., additional, and Smith, Daniel J., additional

Published
2019
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8. Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

Author

Gormley, Padhraig, primary, Anttila, Verneri, additional, Winsvold, Bendik S, additional, Palta, Priit, additional, Esko, Tonu, additional, Pers, Tune H, additional, Farh, Kai-How, additional, Cuenca-Leon, Ester, additional, Muona, Mikko, additional, Furlotte, Nicholas A, additional, Kurth, Tobias, additional, Ingason, Andres, additional, McMahon, George, additional, Ligthart, Lannie, additional, Terwindt, Gisela M, additional, Kallela, Mikko, additional, Freilinger, Tobias M, additional, Ran, Caroline, additional, Gordon, Scott G, additional, Stam, Anine H, additional, Steinberg, Stacy, additional, Borck, Guntram, additional, Koiranen, Markku, additional, Quaye, Lydia, additional, Adams, Hieab HH, additional, Lehtimaki, Terho, additional, Sarin, Antti-Pekka, additional, Wedenoja, Juho, additional, Hinds, David A, additional, Buring, Julie E, additional, Schurks, Markus, additional, Ridker, Paul M, additional, Hrafnsdottir, Maria Gudlaug, additional, Stefansson, Hreinn, additional, Ring, Susan M, additional, Hottenga, Jouke-Jan, additional, Penninx, Brenda WJH, additional, Farkkila, Markus, additional, Artto, Ville, additional, Kaunisto, Mari, additional, Vepsalainen, Salli, additional, Malik, Rainer, additional, Heath, Andrew C, additional, Madden, Pamela AF, additional, Martin, Nicholas G, additional, Montgomery, Grant W, additional, Hamalainen, Eija, additional, Huang, Hailiang, additional, Byrnes, Andrea E, additional, Franke, Lude, additional, Huang, Jie, additional, Stergiakouli, Evie, additional, Lee, Phil H, additional, Sandor, Cynthia, additional, Webber, Caleb, additional, Cader, Zameel, additional, Muller-Myhsok, Bertram, additional, Schreiber, Stefan, additional, Meitinger, Thomas, additional, Eriksson, Johan G, additional, Salomaa, Veikko, additional, Heikkila, Kauko, additional, Loehrer, Elizabeth, additional, Uitterlinden, Andre G, additional, Hofman, Albert, additional, van Duijn, Cornelia M, additional, Cherkas, Lynn, additional, Pedersen, Linda M, additional, Stubhaug, Audun, additional, Nielsen, Christopher S, additional, Mannikko, Minna, additional, Mihailov, Evelin, additional, Milani, Lili, additional, Gobel, Hartmut, additional, Esserlind, Ann-Louise, additional, Christensen, Anne Francke, additional, Hansen, Thomas Folkmann, additional, Werge, Thomas, additional, Kaprio, Jaakko, additional, Aromaa, Arpo J, additional, Raitakari, Olli, additional, Ikram, M Arfan, additional, Spector, Tim, additional, Jarvelin, Marjo-Riitta, additional, Metspalu, Andres, additional, Kubisch, Christian, additional, Strachan, David P, additional, Ferrari, Michel D, additional, Belin, Andrea C, additional, Dichgans, Martin, additional, Wessman, Maija, additional, van den Maagdenberg, Arn MJM, additional, Zwart, John-Anker, additional, Boomsma, Dorret I, additional, Smith, George Davey, additional, Stefansson, Kari, additional, Eriksson, Nicholas, additional, Daly, Mark J, additional, Neale, Benjamin M, additional, Olesen, Jes, additional, Chasman, Daniel I, additional, Nyholt, Dale R, additional, and Palotie, Aarno, additional

Published
2015
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