41 results on '"Wood, Andrew R."'
Search Results
2. Genetic modifiers of rare variants in monogenic developmental disorder loci
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Kingdom, Rebecca, primary, Beaumont, Robin N., additional, Wood, Andrew R., additional, Weedon, Michael N., additional, and Wright, Caroline F., additional
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- 2022
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3. Identification and analysis of individuals who deviate from their genetically-predicted phenotype
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Hawkes, Gareth, Yengo, Loic, Vedantam, Sailaja, Marouli, Eirini, Beaumont, Robin N, Tyrrell, Jessica, Weedon, Michael N, Hirschhorn, Joel, Frayling, Timothy M, and Wood, Andrew R
- Subjects
Article - Abstract
Findings from genome-wide association studies have facilitated the generation of genetic predictors for many common human phenotypes. Stratifying individuals misaligned to a genetic predictor based on common variants may be important for follow-up studies that aim to identify alternative causal factors. Using genome-wide imputed genetic data, we aimed to classify 158,951 unrelated individuals from the UK Biobank as either concordant or deviating from two well-measured phenotypes. We first applied our methods to standing height: our primary analysis classified 244 individuals (0.15%) as misaligned to their genetically predicted height. We show that these individuals are enriched for self-reporting being shorter or taller than average at age 10, diagnosed congenital malformations, and rare loss-of-function variants in genes previously catalogued as causal for growth disorders. Secondly, we apply our methods to LDL cholesterol. We classified 156 (0.12%) individuals as misaligned to their genetically predicted LDL cholesterol and show that these individuals were enriched for both clinically actionable cardiovascular risk factors and rare genetic variants in genes previously shown to be involved in metabolic processes. Individuals whose LDL-C was higher than expected based on the genetic predictor were also at higher risk of developing coronary artery disease and type-two diabetes, even after adjustment for measured LDL-C, BMI and age, suggesting upward deviation from genetically predicted LDL-C is indicative of generally poor health. Our results remained broadly consistent when performing sensitivity analysis based on a variety of parametric and non-parametric methods to define individuals deviating from polygenic expectation. Our analyses demonstrate the potential importance of quantitatively identifying individuals for further follow-up based on deviation from genetic predictions.Author SummaryHuman genetics is becoming increasingly useful to help predict human traits across a population owing to findings from large-scale genetic association studies and advances in the power of genetic predictors. This provides an opportunity to potentially identify individuals that deviate from genetic predictions for a common phenotype under investigation. For example, an individual may be genetically predicted to be tall, but be shorter than expected. It is potentially important to identify individuals who deviate from genetic predictions as this can facilitate further follow-up to assess likely causes. Using 158,951 unrelated individuals from the UK Biobank, with height and LDL cholesterol, as exemplar traits, we demonstrate that approximately 0.15% & 0.12% of individuals deviate from their genetically predicted phenotypes respectively. We observed these individuals to be enriched for a range of rare clinical diagnoses, as well as rare genetic factors that may be causal. Our analyses also demonstrate several methods for detecting individuals who deviate from genetic predictions that can be applied to a range of continuous human phenotypes.
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- 2023
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4. Monogenic causes of Premature Ovarian Insufficiency are rare and mostly recessive
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Shekari, Saleh, primary, Stankovic, Stasa, additional, Gardner, Eugene J., additional, Hawkes, Gareth, additional, Kentistou, Katherine A., additional, Beaumont, Robin N., additional, Mörseburg, Alexander, additional, Wood, Andrew R., additional, Mishra, Gita, additional, Day, Felix, additional, Baptista, Julia, additional, Wright, Caroline F., additional, Weedon, Michael N., additional, Hoffmann, Eva, additional, Ruth, Katherine S., additional, Ong, Ken, additional, Perry, John R. B., additional, and Murray, Anna, additional
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- 2022
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5. The causal role of accelerometer-derived sleep traits on glycated haemoglobin: a Mendelian randomization study
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Liu, Junxi, primary, Richmond, Rebecca C, additional, Anderson, Emma L, additional, Bowden, Jack, additional, Barry, Ciarrah-Jane S, additional, Dashti, Hassan S, additional, Daghlas, Iyas S, additional, Lane, Jacqueline M, additional, Kyle, Simon D, additional, Vetter, Céline, additional, Morrison, Claire L, additional, Jones, Samuel E, additional, Wood, Andrew R, additional, Frayling, Timothy M, additional, Wright, Alison K, additional, Carr, Matthew J, additional, Anderson, Simon G, additional, Emsley, Richard A, additional, Ray, David W, additional, Weedon, Michael N, additional, Saxena, Richa, additional, Rutter, Martin K, additional, and Lawlor, Deborah A, additional
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- 2022
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6. Study of the associations between short telomeres, sex hormones and pulmonary fibrosis
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Duckworth, Anna, primary, Ruth, Katherine S., additional, Prague, Julia K., additional, Russell, Anne-Marie, additional, Almond, Howard, additional, Conway, John, additional, Beaumont, Robin N, additional, Wood, Andrew R, additional, Martin, Susan, additional, Lunnon, Katie, additional, Lindsay, Mark A., additional, Murray, Anna, additional, Gibbons, Michael A., additional, Tyrrell, Jess, additional, and Scotton, Chris J., additional
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- 2022
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7. Genomic insights into the mechanism of NK3R antagonists for treatment of menopausal vasomotor symptoms
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Ruth, Katherine S., primary, Beaumont, Robin N., additional, Locke, Jonathan M., additional, Tyrrell, Jessica, additional, Crandall, Carolyn J., additional, Hawkes, Gareth, additional, Frayling, Timothy M., additional, Prague, Julia K., additional, Patel, Kashyap A., additional, Wood, Andrew R., additional, Weedon, Michael N., additional, and Murray, Anna, additional
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- 2022
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8. The impact of Mendelian sleep and circadian genetic variants in a population setting
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Weedon, Michael N., primary, Jones, Samuel E., additional, Lane, Jacqueline. M., additional, Lee, Jiwon, additional, Ollila, Hanna M., additional, Dawes, Amy, additional, Tyrrell, Jess, additional, Beaumont, Robin N., additional, Partonen, Timo, additional, Merikanto, Ilona, additional, Rich, Stephen S., additional, Rotter, Jerome I., additional, Frayling, Timothy M., additional, Rutter, Martin K, additional, Redline, Susan, additional, Sofer, Tamar, additional, Saxena, Richa, additional, and Wood, Andrew R., additional
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- 2022
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9. Rare genetic variants in dominant developmental disorder loci cause milder related phenotypes in the general population
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Kingdom, Rebecca, primary, Tuke, Marcus A, additional, Wood, Andrew R, additional, Beaumont, Robin N, additional, Frayling, Timothy R, additional, Weedon, Michael N, additional, and Wright, Caroline F, additional
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- 2021
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10. The penetrance of age-related monogenic disease depends on ascertainment context
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Mirshahi, Uyenlinh L, primary, Colclough, Kevin, additional, Wright, Caroline F, additional, Wood, Andrew R, additional, Beaumont, Robin N, additional, Tyrrell, Jessica, additional, Laver, Thomas W, additional, Stahl, Richard, additional, Golden, Alicia, additional, Goehringer, Jessica M, additional, Frayling, Timothy F, additional, Hattersley, Andrew T, additional, Carey, David J, additional, Weedon, Michael N, additional, and Patel, Kashyap A, additional
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- 2021
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11. Associations of genetic scores for birth weight with newborn size and later Anthropometric traits and cardiometabolic risk markers in South Asians
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Nongmaithem, Suraj S, primary, Beaumont, Robin N, additional, Dedaniya, Akshay, additional, Wood, Andrew R, additional, Ogunkolade, Babatunji-William, additional, Hassan, Zahid, additional, Krishnaveni, Ghattu V, additional, Kumaran, Kalyanaraman, additional, Potdar, Ramesh D, additional, Sahariah, Sirajul A, additional, Krishna, Murali, additional, Di Gravio, Chiara, additional, Mali, Inder D, additional, Sankareswaran, Alagu, additional, Hussain, Akhtar, additional, Bhowmik, Biswajit W, additional, Khan, Abdul Kalam A, additional, Knight, Bridget A, additional, Frayling, Timothy M, additional, Finer, Sarah, additional, Fall, Caroline HD, additional, Yajnik, Chittaranjan S, additional, Freathy, Rachel M, additional, Hitman, Graham A, additional, and Chandak, Giriraj R, additional
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- 2021
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12. Assessing the causal role of sleep traits on glycated haemoglobin: a Mendelian randomization study
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Liu, Junxi, primary, Richmond, Rebecca C, additional, Bowden, Jack, additional, Barry, Ciarrah, additional, Dashti, Hassan S, additional, Daghlas, Iyas, additional, Lane, Jacqueline M, additional, Jones, Samuel E, additional, Wood, Andrew R, additional, Frayling, Timothy M, additional, Wright, Alison K, additional, Carr, Matthew J, additional, Anderson, Simon G, additional, Emsley, Richard, additional, Ray, David, additional, Weedon, Michael N, additional, Saxena, Richa, additional, Lawlor, Deborah A, additional, and Rutter, Martin K, additional
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- 2020
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13. A Mendelian randomisation study of smoking causality in IPF compared with COPD
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Duckworth, Anna, primary, Gibbons, Michael A., additional, Beaumont, Robin N, additional, Wood, Andrew R, additional, Almond, Howard, additional, Lunnon, Katie, additional, Lindsay, Mark A., additional, Scotton, Chris J, additional, and Tyrrell, Jess, additional
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- 2020
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14. A genome wide association study of frozen shoulder identifies a common variant of WNT7B and diabetes as causal risk factors
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Green, Harry D, primary, Jones, Alistair, additional, Evans, Jonathan P, additional, Wood, Andrew R, additional, Beaumont, Robin N, additional, Tyrrell, Jessica, additional, Frayling, Timothy M, additional, Smith, Chris, additional, and Weedon, Michael N, additional
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- 2020
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15. Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome
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Porcu, Eleonora, primary, Sadler, Marie C., additional, Lepik, Kaido, additional, Auwerx, Chiara, additional, Wood, Andrew R., additional, Weihs, Antoine, additional, Ribeiro, Diogo M., additional, Bandinelli, Stefania, additional, Tanaka, Toshiko, additional, Nauck, Matthias, additional, Völker, Uwe, additional, Delaneau, Olivier, additional, Metspalu, Andres, additional, Teumer, Alexander, additional, Frayling, Timothy, additional, Santoni, Federico A., additional, Reymond, Alexandre, additional, and Kutalik, Zoltán, additional
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- 2020
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16. The Trans-Ancestral Genomic Architecture of Glycaemic Traits
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Chen, Ji, primary, Spracklen, Cassandra N., additional, Marenne, Gaëlle, additional, Varshney, Arushi, additional, Corbin, Laura J, additional, Luan, Jian’an, additional, Willems, Sara, additional, Wu, Ying, additional, Zhang, Xiaoshuai, additional, Horikoshi, Momoko, additional, Boutin, Thibaud S, additional, Mägi, Reedik, additional, Waage, Johannes, additional, Pitsilides, Achilleas, additional, Li-Gao, Ruifang, additional, Hang, Kei, additional, Yao, Jie, additional, Anasanti, Mila D, additional, Chu, Audrey Y, additional, Claringbould, Annique, additional, Heikkinen, Jani, additional, Hong, Jaeyoung, additional, Hottenga, Jouke-Jan, additional, Huo, Shaofeng, additional, Kaakinen, Marika A., additional, Louie, Tin, additional, März, Winfried, additional, Moreno-Macias, Hortensia, additional, Ndungu, Anne, additional, Nelson, Sarah C., additional, Nolte, Ilja M., additional, North, Kari, additional, Raulerson, Chelsea K., additional, Ray, Debashree, additional, Rohde, Rebecca, additional, Rybin, Denis, additional, Schurmann, Claudia, additional, Sim, Xueling, additional, Southam, Loz, additional, Stewart, Isobel, additional, Wang, Carol A., additional, Wang, Yujie, additional, Wu, Peitao, additional, Zhang, Weihua, additional, Ahluwalia, Tarunveer S., additional, Appel, Emil VR, additional, Bielak, Lawrence F., additional, Brody, Jennifer A., additional, Burtt, Noel P, additional, Cabrera, Claudia P, additional, Cade, Brian E, additional, Chai, Jin Fang, additional, Chai, Xiaoran, additional, Chang, Li-Ching, additional, Chen, Chien-Hsiun, additional, Chen, Brian H, additional, Chitrala, Kumaraswamy N, additional, Chiu, Yen-Feng, additional, de Haan, Hugoline G., additional, Delgado, Graciela E, additional, Demirkan, Ayse, additional, Duan, Qing, additional, Engmann, Jorgen, additional, Fatumo, Segun A, additional, Gayán, Javier, additional, Giulianini, Franco, additional, Gong, Jung Ho, additional, Gustafsson, Stefan, additional, Hai, Yang, additional, Hartwig, Fernando P, additional, He, Jing, additional, Heianza, Yoriko, additional, Huang, Tao, additional, Huerta-Chagoya, Alicia, additional, Hwang, Mi Yeong, additional, Jensen, Richard A., additional, Kawaguchi, Takahisa, additional, Kentistou, Katherine A, additional, Kim, Young Jin, additional, Kleber, Marcus E, additional, Kooner, Ishminder K, additional, Lai, Shuiqing, additional, Lange, Leslie A, additional, Langefeld, Carl D, additional, Lauzon, Marie, additional, Li, Man, additional, Ligthart, Symen, additional, Liu, Jun, additional, Loh, Marie, additional, Long, Jirong, additional, Lyssenko, Valeriya, additional, Mangino, Massimo, additional, Marzi, Carola, additional, Montasser, May E, additional, Nag, Abhishek, additional, Nakatochi, Masahiro, additional, Noce, Damia, additional, Noordam, Raymond, additional, Pistis, Giorgio, additional, Preuss, Michael, additional, Raffield, Laura, additional, Rasmussen-Torvik, Laura J., additional, Rich, Stephen S, additional, Robertson, Neil R, additional, Rueedi, Rico, additional, Ryan, Kathleen, additional, Sanna, Serena, additional, Saxena, Richa, additional, Schraut, Katharina E, additional, Sennblad, Bengt, additional, Setoh, Kazuya, additional, Smith, Albert V, additional, Southam, Lorraine, additional, Sparsø, Thomas, additional, Strawbridge, Rona J, additional, Takeuchi, Fumihiko, additional, Tan, Jingyi, additional, Trompet, Stella, additional, van den Akker, Erik, additional, Van der Most, Peter J, additional, Verweij, Niek, additional, Vogel, Mandy, additional, Wang, Heming, additional, Wang, Chaolong, additional, Wang, Nan, additional, Warren, Helen R, additional, Wen, Wanqing, additional, Wilsgaard, Tom, additional, Wong, Andrew, additional, Wood, Andrew R, additional, Xie, Tian, additional, Zafarmand, Mohammad Hadi, additional, Zhao, Jing-Hua, additional, Zhao, Wei, additional, Amin, Najaf, additional, Arzumanyan, Zorayr, additional, Astrup, Arne, additional, Bakker, Stephan JL, additional, Baldassarre, Damiano, additional, Beekman, Marian, additional, Bergman, Richard N, additional, Bertoni, Alain, additional, Blüher, Matthias, additional, Bonnycastle, Lori L., additional, Bornstein, Stefan R, additional, Bowden, Donald W, additional, Cai, Qiuyin, additional, Campbell, Archie, additional, Campbell, Harry, additional, Chang, Yi Cheng, additional, de Geus, Eco J.C., additional, Dehghan, Abbas, additional, Du, Shufa, additional, Eiriksdottir, Gudny, additional, Farmaki, Aliki Eleni, additional, Frånberg, Mattias, additional, Fuchsberger, Christian, additional, Gao, Yutang, additional, Gjesing, Anette P, additional, Goel, Anuj, additional, Han, Sohee, additional, Hartman, Catharina A, additional, Herder, Christian, additional, Hicks, Andrew A., additional, Hsieh, Chang-Hsun, additional, Hsueh, Willa A., additional, Ichihara, Sahoko, additional, Igase, Michiya, additional, Ikram, M. Arfan, additional, Johnson, W. Craig, additional, Jørgensen, Marit E, additional, Joshi, Peter K, additional, Kalyani, Rita R, additional, Kandeel, Fouad R., additional, Katsuya, Tomohiro, additional, Khor, Chiea Chuen, additional, Kiess, Wieland, additional, Kolcic, Ivana, additional, Kuulasmaa, Teemu, additional, Kuusisto, Johanna, additional, Läll, Kristi, additional, Lam, Kelvin, additional, Lawlor, Deborah A, additional, Lee, Nanette R., additional, Lemaitre, Rozenn N., additional, Li, Honglan, additional, Study, Lifelines Cohort, additional, Lin, Shih-Yi, additional, Lindström, Jaana, additional, Linneberg, Allan, additional, Liu, Jianjun, additional, Lorenzo, Carlos, additional, Matsubara, Tatsuaki, additional, Matsuda, Fumihiko, additional, Mingrone, Geltrude, additional, Mooijaart, Simon, additional, Moon, Sanghoon, additional, Nabika, Toru, additional, Nadkarni, Girish N., additional, Nadler, Jerry L., additional, Nelis, Mari, additional, Neville, Matthew J, additional, Norris, Jill M, additional, Ohyagi, Yasumasa, additional, Peters, Annette, additional, Peyser, Patricia A., additional, Polasek, Ozren, additional, Qi, Qibin, additional, Raven, Dennis, additional, Reilly, Dermot F, additional, Reiner, Alex, additional, Rivideneira, Fernando, additional, Roll, Kathryn, additional, Rudan, Igor, additional, Sabanayagam, Charumathi, additional, Sandow, Kevin, additional, Sattar, Naveed, additional, Schürmann, Annette, additional, Shi, Jinxiu, additional, Stringham, Heather M, additional, Taylor, Kent D., additional, Teslovich, Tanya M., additional, Thuesen, Betina, additional, Timmers, Paul RHJ, additional, Tremoli, Elena, additional, Tsai, Michael Y, additional, Uitterlinden, Andre, additional, van Dam, Rob M, additional, van Heemst, Diana, additional, van Hylckama Vlieg, Astrid, additional, Van Vliet-Ostaptchouk, Jana V, additional, Vangipurapu, Jagadish, additional, Vestergaard, Henrik, additional, Wang, Tao, additional, van Dijk, Ko Willems, additional, Xiang, Yongbing, additional, Zemunik, Tatijana, additional, Abecasis, Goncalo R, additional, Adair, Linda S., additional, Aguilar-Salinas, Carlos Alberto, additional, Alarcón-Riquelme, Marta E, additional, An, Ping, additional, Aviles-Santa, Larissa, additional, Becker, Diane M, additional, Beilin, Lawrence J, additional, Bergmann, Sven, additional, Bisgaard, Hans, additional, Black, Corri, additional, Boehnke, Michael, additional, Boerwinkle, Eric, additional, Böhm, Bernhard O, additional, Bønnelykke, Klaus, additional, Boomsma, D I., additional, Bottinger, Erwin P., additional, Buchanan, Thomas A, additional, Canouil, Mickaël, additional, Caulfield, Mark J, additional, Chambers, John C., additional, Chasman, Daniel I., additional, Chen, Yii-Der Ida, additional, Cheng, Ching-Yu, additional, Collins, Francis S., additional, Correa, Adolfo, additional, Cucca, Francesco, additional, de Silva, H. Janaka, additional, Dedoussis, George, additional, Elmståhl, Sölve, additional, Evans, Michele K., additional, Ferranni, Ele, additional, Ferruci, Luigi, additional, Florez, Jose C, additional, Franks, Paul, additional, Frayling, Timothy M, additional, Froguel, Philippe, additional, Gigante, Bruna, additional, Goodarzi, Mark O., additional, Gordon-Larsen, Penny, additional, Grallert, Harald, additional, Grarup, Niels, additional, Grimsgaard, Sameline, additional, Groop, Leif, additional, Gudnason, Vilmundur, additional, Guo, Xiuqing, additional, Hamsten, Anders, additional, Hansen, Torben, additional, Hayward, Caroline, additional, Heckbert, Susan R., additional, Horta, Bernardo L, additional, Huang, Wei, additional, Ingelsson, Erik, additional, James, Pankow S, additional, Jonas, Jost B, additional, Jukema, J. Wouter, additional, Kaleebu, Pontiano, additional, Kaplan, Robert, additional, Kardia, Sharon L.R., additional, Kato, Norihiro, additional, Keinanen-Kiukaanniemi, Sirkka M., additional, Kim, Bong-Jo, additional, Kivimaki, Mika, additional, Koistinen, Heikki A., additional, Kooner, Jaspal S., additional, Körner, Antje, additional, Kovacs, Peter, additional, Kuh, Diana, additional, Kumari, Meena, additional, Kutalik, Zoltan, additional, Laakso, Markku, additional, Lakka, Timo A., additional, Launer, Lenore J, additional, Leander, Karin, additional, Li, Huaixing, additional, Lin, Xu, additional, Lind, Lars, additional, Lindgren, Cecilia, additional, Liu, Simin, additional, Loos, Ruth J.F., additional, Magnusson, Patrik, additional, Mahajan, Anubha, additional, Metspalu, Andres, additional, Mook-Kanamori, Dennis O, additional, Mori, Trevor A, additional, Munroe, Patricia B, additional, Njølstad, Inger, additional, O’Connell, Jeffrey R, additional, Oldehinkel, Albertine J, additional, Ong, Ken K, additional, Padmanabhan, Sandosh, additional, Palmer, Colin N.A., additional, Palmer, Nicholette D, additional, Pedersen, Oluf, additional, Pennell, Craig E, additional, Porteous, David J, additional, Pramstaller, Peter P., additional, Province, Michael A., additional, Psaty, Bruce M., additional, Qi, Lu, additional, Raffel, Leslie J., additional, Rauramaa, Rainer, additional, Redline, Susan, additional, Ridker, Paul M, additional, Rosendaal, Frits R., additional, Saaristo, Timo E., additional, Sandhu, Manjinder, additional, Saramies, Jouko, additional, Schneiderman, Neil, additional, Schwarz, Peter, additional, Scott, Laura J., additional, Selvin, Elizabeth, additional, Sever, Peter, additional, Shu, Xiao-ou, additional, Slagboom, P Eline, additional, Small, Kerrin S, additional, Smith, Blair H, additional, Snieder, Harold, additional, Sofer, Tamar, additional, Sørensen, Thorkild I.A., additional, Spector, Tim D, additional, Stanton, Alice, additional, Steves, Claire J, additional, Stumvoll, Michael, additional, Sun, Liang, additional, Tabara, Yasuharu, additional, Tai, E Shyong, additional, Timpson, Nicholas J, additional, Tönjes, Anke, additional, Tuomilehto, Jaakko, additional, Tusie, Teresa, additional, Uusitupa, Matti, additional, van der Harst, Pim, additional, van Duijn, Cornelia, additional, Vitart, Veronique, additional, Vollenweider, Peter, additional, Vrijkotte, Tanja GM, additional, Wagenknecht, Lynne E, additional, Walker, Mark, additional, Wang, Ya X, additional, Wareham, Nick J, additional, Watanabe, Richard M, additional, Watkins, Hugh, additional, Wei, Wen B, additional, Wickremasinghe, Ananda R, additional, Willemsen, Gonneke, additional, Wilson, James F, additional, Wong, Tien-Yin, additional, Wu, Jer-Yuarn, additional, Xiang, Anny H, additional, Yanek, Lisa R, additional, Yengo, Loïc, additional, Yokota, Mitsuhiro, additional, Zeggini, Eleftheria, additional, Zheng, Wei, additional, Zonderman, Alan B, additional, Rotter, Jerome I, additional, Gloyn, Anna L, additional, McCarthy, Mark I., additional, Dupuis, Josée, additional, Meigs, James B, additional, Scott, Robert, additional, Prokopenko, Inga, additional, Leong, Aaron, additional, Liu, Ching-Ti, additional, Parker, Stephen CJ, additional, Mohlke, Karen L., additional, Langenberg, Claudia, additional, Wheeler, Eleanor, additional, Morris, Andrew P., additional, and Barroso, Inês, additional
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- 2020
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17. Common maternal and fetal genetic variants show expected polygenic effects on the probability of being born small- or large-for-gestational-age (SGA or LGA), except in the smallest 3% of babies
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Beaumont, Robin N, primary, Kotecha, Sarah J, additional, Wood, Andrew R., additional, Knight, Bridget A., additional, Sebert, Sylvain, additional, McCarthy, Mark I., additional, Hattersley, Andrew T., additional, Järvelin, Marjo-Riitta, additional, Timpson, Nicholas J., additional, Freathy, Rachel M, additional, and Kotecha, Sailesh, additional
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- 2020
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18. Genetic predictors of participation in optional components of UK Biobank
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Tyrrell, Jessica, primary, Zheng, Jie, additional, Beaumont, Robin, additional, Hinton, Kathryn, additional, Richardson, Tom G, additional, Wood, Andrew R, additional, Smith, George Davey, additional, Frayling, Timothy M, additional, and Tilling, Kate, additional
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- 2020
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19. Evidence that Telomere Length is Causal for Idiopathic Pulmonary Fibrosis but not Chronic Obstructive Pulmonary Disease: A Mendelian Randomisation Study
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Duckworth, Anna, primary, Gibbons, Michael A., additional, Allen, Richard J., additional, Almond, Howard, additional, Beaumont, Robin N., additional, Wood, Andrew R., additional, Lunnon, Katie, additional, Lindsay, Mark A., additional, Wain, Louise V., additional, Tyrrell, Jess, additional, and Scotton, Chris J., additional
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- 2020
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20. Genome-wide association analyses of chronotype in 697,828 individuals provides new insights into circadian rhythms in humans and links to disease
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Jones, Samuel E., Lane, Jacqueline M., Wood, Andrew R., van Hees, Vincent T., Tyrrell, Jessica, Beaumont, Robin N., Jefferies, Aaron, Dashti, Hassan S., Hillsdon, Melvyn, Ruth, Katherine S., Tuke, Marcus A., Yaghootkar, Hanieh, Sharp, Seth, Jie, Yingjie, Thompson, William D., Harrison, Jamie W., Dawes, Amy, Byrne, Enda M., Tiemeier, Henning, Allebrandt, Karla V., Bowden, Jack, Ray, David W., Freathy, Rachel M., Murray, Anna, Mazzotti, Diego R., Gehrman, Philip R., Lawlor, Debbie A., Frayling, Timothy M., Rutter, Martin K., Hinds, David, Saxena, Richa, and Weedon, Michael N.
- Subjects
Genetics ,0303 health sciences ,Chronotype ,Genome-wide association study ,Disease ,Biology ,Affect (psychology) ,Sleep in non-human animals ,03 medical and health sciences ,0302 clinical medicine ,Circadian rhythm ,Allele ,030217 neurology & neurosurgery ,030304 developmental biology ,Morning - Abstract
Using genome-wide data from 697,828 research participants from 23andMe and UK Biobank, we increase the number of identified loci associated with being a morning person, a behavioural indicator of a person’s underlying circadian rhythm, from 24 to 351. Using data from 85,760 individuals with activity-monitor derived measures of sleep timing we show that the chronotype loci influence sleep timing: the mean sleep timing of the 5% of individuals carrying the most “morningness” alleles was 25 minutes earlier than the 5% carrying the fewest. The loci were enriched for genes involved in circadian regulation, cAMP, glutamate and insulin signalling pathways, and those expressed in the retina, hindbrain, hypothalamus, and pituitary. We provide evidence that being a morning person is causally associated with better mental health but does not appear to affect BMI or Type 2 diabetes. This study offers new insights into the biology of circadian rhythms and links to disease in humans.
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- 2018
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21. Maximum likelihood method quantifies the overall contribution of gene-environment interaction to continuous traits: an application to complex traits in the UK Biobank
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Sulc, Jonathan, primary, Mounier, Ninon, additional, Günther, Felix, additional, Winkler, Thomas, additional, Wood, Andrew R., additional, Frayling, Timothy M., additional, Heid, Iris M., additional, Robinson, Matthew R., additional, and Kutalik, Zoltán, additional
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- 2019
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22. Is disrupted sleep a risk factor for Alzheimer’s disease? Evidence from a two-sample Mendelian randomization analysis
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Anderson, Emma L, primary, Richmond, Rebecca C, additional, Jones, Samuel E, additional, Hemani, Gibran, additional, Wade, Kaitlin. H, additional, Dashti, Hassan S, additional, Lane, Jacqueline M, additional, Wang, Heming, additional, Saxena, Richa, additional, Brumpton, Ben, additional, Korologou-Linden, Roxanna, additional, Nielson, Jonas B, additional, Olav Åsvold, Bjørn, additional, Abecasis, Gonçalo, additional, Coulthard, Elizabeth, additional, Kyle, Simon D., additional, Beaumont, Robin N, additional, Tyrrell, Jessica, additional, Frayling, Timothy M, additional, Munafò, Marcus R, additional, Wood, Andrew R, additional, Ben-Shlomo, Yoav, additional, Howe, Laura D, additional, Lawlor, Debbie A, additional, Weedon, Michael N, additional, and Davey Smith, George, additional
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- 2019
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23. Effects of body mass index on relationship status, social contact, and socioeconomic position: Mendelian Randomization study in UK Biobank
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Howe, Laura D, primary, Kanayalal, Roshni, additional, Beaumont, Robin N, additional, Davies, Alisha R, additional, Frayling, Timothy M, additional, Harrison, Sean, additional, Jones, Samuel E, additional, Sassi, Franco, additional, Wood, Andrew R, additional, and Tyrrell, Jessica, additional
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- 2019
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24. Investigating causal relationships between sleep traits and risk of breast cancer: a Mendelian randomization study
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Richmond, Rebecca C., primary, Anderson, Emma L., additional, Dashti, Hassan S., additional, Jones, Samuel E., additional, Lane, Jacqueline M., additional, Strand, Linn Beate, additional, Brumpton, Ben, additional, Rutter, Martin, additional, Wood, Andrew R., additional, Relton, Caroline L., additional, Munafò, Marcus, additional, Frayling, Timothy M., additional, Martin, Richard M., additional, Saxena, Richa, additional, Weedon, Michael N., additional, Lawlor, Debbie A., additional, and Davey Smith, George, additional
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- 2018
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25. Genome-wide association analysis of excessive daytime sleepiness identifies 42 loci that suggest phenotypic subgroups
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Wang, Heming, primary, Lane, Jacqueline M, additional, Jones, Samuel E, additional, Dashti, Hassan S, additional, Ollila, Hanna, additional, Wood, Andrew R, additional, van Hees, Vincent T., additional, Brumpton, Ben, additional, Winsvold, Bendik S, additional, Kantojärvi, Katri, additional, Cade, Brian E, additional, Sofer, Tamar, additional, Song, Yanwei, additional, Patel, Krunal, additional, Anderson, Simon G, additional, Bechtold, David A, additional, Bowden, Jack, additional, Emsley, Richard, additional, Kyle, Simon D, additional, Little, Max A, additional, Loudon, Andrew S, additional, Scheer, Frank AJL, additional, Purcell, Shaun M, additional, Richmond, Rebecca C, additional, Spiegelhalder, Kai, additional, Tyrrell, Jessica, additional, Zhu, Xiaofeng, additional, Kristiansson, Kati, additional, Sulkava, Sonja, additional, Paunio, Tiina, additional, Hveem, Kristian, additional, Nielsen, Jonas B, additional, Willer, Cristen J, additional, Zwart, John-Anker, additional, Strand, Linn B, additional, Frayling, Timothy M, additional, Ray, David, additional, Lawlor, Deborah A, additional, Rutter, Martin K, additional, Weedon, Michael N, additional, Redline, Susan, additional, and Saxena, Richa, additional
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- 2018
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26. Assessing the pathogenicity, penetrance and expressivity of putative disease-causing variants in a population setting
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Wright, Caroline F., primary, West, Ben, additional, Tuke, Marcus, additional, Jones, Samuel E., additional, Patel, Kashyap, additional, Laver, Thomas W., additional, Beaumont, R. N., additional, Tyrrell, Jessica, additional, Wood, Andrew R., additional, Frayling, Timothy M., additional, Hattersley, Andrew T., additional, and Weedon, Michael N., additional
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- 2018
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27. Genetic studies of accelerometer-based sleep measures in 85,670 individuals yield new insights into human sleep behaviour
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Jones, Samuel E., primary, Hees, Vincent T. van, additional, Mazzotti, Diego R., additional, Marques-Vidal, Pedro, additional, Sabia, Séverine, additional, der Spek, Ashley van, additional, Dashti, Hassan S., additional, Engmann, Jorgen, additional, Kocevska, Desana, additional, Tyrrell, Jessica, additional, Beaumont, Robin N., additional, Hillsdon, Melvyn, additional, Ruth, Katherine S., additional, Tuke, Marcus A., additional, Yaghootkar, Hanieh, additional, Sharp, Seth, additional, Jie, Yingjie, additional, Harrison, Jamie W., additional, Freathy, Rachel M., additional, Murray, Anna, additional, Luik, Annemarie I., additional, Amin, Najaf, additional, Lane, Jacqueline M., additional, Saxena, Richa, additional, Rutter, Martin K., additional, Tiemeier, Henning, additional, Kutalik, Zoltan, additional, Kumari, Meena, additional, Frayling, Timothy M., additional, Weedon, Michael N., additional, Gehrman, Philip, additional, and Wood, Andrew R., additional
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- 2018
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28. GWAS in 446,118 European adults identifies 78 genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates
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Dashti, Hassan S, primary, Jones, Samuel E, additional, Wood, Andrew R, additional, Lane, Jacqueline M, additional, van Hees, Vincent T., additional, Wang, Heming, additional, Rhodes, Jessica A, additional, Song, Yanwei, additional, Patel, Krunal, additional, Anderson, Simon G, additional, Beaumont, Robin, additional, Bechtold, David A, additional, Bowden, Jack, additional, Cade, Brian E, additional, Garaulet, Marta, additional, Kyle, Simon D, additional, Little, Max A, additional, Loudon, Andrew S, additional, Luik, Annemarie I, additional, Scheer, Frank AJL, additional, Spiegelhalder, Kai, additional, Tyrrell, Jessica, additional, Gottlieb, Daniel J, additional, Tiemeier, Henning, additional, Ray, David W, additional, Purcell, Shaun M, additional, Frayling, Timothy M, additional, Redline, Susan, additional, Lawlor, Deborah A, additional, Rutter, Martin K, additional, Weedon, Michael N, additional, and Saxena, Richa, additional
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- 2018
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29. Meta-analysis of genome-wide association studies for body fat distribution in 694,649 individuals of European ancestry
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Pulit, Sara L., primary, Stoneman, Charli, additional, Morris, Andrew P., additional, Wood, Andrew R., additional, Glastonbury, Craig A., additional, Tyrrell, Jessica, additional, Yengo, Loïc, additional, Ferreira, Teresa, additional, Marouli, Eirini, additional, Ji, Yingjie, additional, Yang, Jian, additional, Jones, Samuel, additional, Beaumont, Robin, additional, Croteau-Chonka, Damien C., additional, Winkler, Thomas W., additional, Consortium, Giant, additional, Hattersley, Andrew. T., additional, Loos, Ruth J. F., additional, Hirschhorn, Joel N., additional, Visscher, Peter M., additional, Frayling, Timothy M., additional, Yaghootkar, Hanieh, additional, and Lindgren, Cecilia M., additional
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- 2018
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30. GWAS identifies novel risk locus for erectile dysfunction and implicates hypothalamic neurobiology and diabetes in etiology
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Bovijn, Jonas, primary, Jackson, Leigh, additional, Censin, Jenny, additional, Chen, Chia-Yen, additional, Laisk-Podar, Triin, additional, Laber, Samantha, additional, Ferreira, Teresa, additional, Glastonbury, Craig, additional, Smoller, Jordan, additional, Harrison, Jamie W, additional, Ruth, Katherine S, additional, Beaumont, Robin N, additional, Jones, Samuel E, additional, Tyrrell, Jessica, additional, Wood, Andrew R, additional, Weedon, Michael N, additional, Mägi, Reedik, additional, Neale, Benjamin, additional, Lindgren, Cecilia M, additional, Murray, Anna, additional, and Holmes, Michael V, additional
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- 2018
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31. Evidence of a common causal relationship between body mass index and inflammatory skin disease: a Mendelian Randomization study
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Budu-Aggrey, Ashley, primary, Brumpton, Ben, additional, Tyrrell, Jess, additional, Watkins, Sarah, additional, Modalsli, Ellen H, additional, Celis-Morales, Carlos, additional, Ferguson, Lyn D, additional, Vie, Gunnhild Åberge, additional, Palmer, Tom, additional, Fritsche, Lars G, additional, Løset, Mari, additional, Nielsen, Jonas Bille, additional, Zhou, Wei, additional, Tsoi, Lam C, additional, Wood, Andrew R, additional, Jones, Samuel E, additional, Beaumont, Robin, additional, Saunes, Marit, additional, Romundstad, Pål Richard, additional, Siebert, Stefan, additional, McInnes, Iain B, additional, Elder, James T, additional, Smith, George Davey, additional, Frayling, Timothy M, additional, Åsvold, Bjørn Olav, additional, Brown, Sara J, additional, Sattar, Naveed, additional, and Paternoster, Lavinia, additional
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- 2018
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32. A common allele in FGF21 associated with preference for sugar consumption lowers body fat in the lower body and increases blood pressure
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Frayling, Timothy M., primary, Beaumont, Robin N., additional, Jones, Samuel E., additional, Yaghootkar, Hanieh, additional, Tuke, Marcus A., additional, Ruth, Katherine S., additional, Casanova, Francesco, additional, West, Ben, additional, Locke, Jonathan, additional, Sharp, Seth, additional, Ji, Yingjie, additional, Thompson, William, additional, Harrison, Jamie, additional, Lindgren, Cecilia M., additional, Grarup, Niels, additional, Murray, Anna, additional, Freathy, Rachel M., additional, Weedon, Michael N., additional, Tyrrell, Jessica, additional, and Wood, Andrew R., additional
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- 2017
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33. Mosaic Turner syndrome shows reduced phenotypic penetrance in an adult population study compared to clinically ascertained cases
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Tuke, Marcus A., primary, Ruth, Katherine S., additional, Wood, Andrew R., additional, Beaumont, Robin N., additional, Tyrrell, Jessica, additional, Jones, Samuel E., additional, Yaghootkar, Hanieh, additional, Turner, Claire L.S., additional, Donohoe, Mollie E., additional, Brooke, Antonia M., additional, Collinson, Morag N., additional, Freathy, Rachel M., additional, Weedon, Michael N., additional, Frayling, Timothy M., additional, and Murray, Anna, additional
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- 2017
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34. Red Blood Cell Distribution Width: genetic evidence for aging pathways in 116,666 volunteers
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Pilling, Luke C., primary, Atkins, Janice L., additional, Duff, Michael O., additional, Beaumont, Robin N., additional, Jones, Samuel E., additional, Tyrrell, Jessica, additional, Kuo, Chia-Ling, additional, Ruth, Katherine S., additional, Tuke, Marcus A., additional, Yaghootkar, Hanieh, additional, Wood, Andrew R., additional, Murray, Anna, additional, Weedon, Michael N., additional, Harries, Lorna W., additional, Kuchel, George A., additional, Ferrucci, Luigi, additional, Frayling, Timothy M., additional, and Melzer, David, additional
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- 2017
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35. Evidence that lower socioeconomic position accentuates genetic susceptibility to obesity
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Tyrrell, Jessica, primary, Wood, Andrew R, additional, Ames, Ryan M, additional, Yaghootkar, Hanieh, additional, Beaumont, Robin N., additional, Jones, Samuel E., additional, Tuke, Marcus A, additional, Ruth, Katherine S., additional, Freathy, Rachel M, additional, Smith, George Davey, additional, Joost, Stéphane, additional, Guessous, Idris, additional, Murray, Anna, additional, Strachan, David P., additional, Kutalik, Zoltán, additional, Weedon, Michael N, additional, and Frayling, Timothy M, additional
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- 2016
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36. Quantifying the extent to which index event biases influence large genetic association studies
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Yaghootkar, Hanieh, primary, Bancks, Michael P., additional, Jones, Sam E., additional, McDaid, Aaron, additional, Beaumont, Robin, additional, Donnelly, Louise, additional, Wood, Andrew R., additional, Campbell, Archie, additional, Tyrrell, Jessica, additional, Hocking, Lynne J., additional, Tuke, Marcus A., additional, Ruth, Katherine S., additional, Pearson, Ewan R., additional, Murray, Anna, additional, Freathy, Rachel M., additional, Munroe, Patricia B., additional, Hayward, Caroline, additional, Palmer, Colin, additional, Weedon, Michael N., additional, Pankow, James S., additional, Frayling, Timothy M., additional, and Kutalik, Zoltán, additional
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- 2016
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37. Genome-wide association analyses in >119,000 individuals identifies thirteen morningness and two sleep duration loci
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Jones, Samuel E, primary, Tyrrell, Jessica, additional, Wood, Andrew R, additional, Beaumont, Robin N, additional, Ruth, Katherine S, additional, Tuke, Marcus A, additional, Yaghootkar, Hanieh, additional, Hu, Youna, additional, Teder-Laving, Maris, additional, Hayward, Caroline, additional, Roenneberg, Till, additional, Wilson, James F, additional, Del Greco, Fabiola, additional, Hicks, Andrew A, additional, Shin, Chol, additional, Yun, Chang-Ho, additional, Ku Lee, Seung, additional, Metspalu, Andres, additional, Byrne, Enda M, additional, Gehrman, Philip R, additional, Tiemeier, Henning, additional, Allebrandt, Karla V, additional, Freathy, Rachel M, additional, Murray, Anna, additional, Hinds, David A, additional, Frayling, Timothy M, additional, and Weedon, Michael N, additional
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- 2016
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38. HUMAN LONGEVITY IS INFLUENCED BY MANY GENETIC VARIANTS: EVIDENCE FROM 75,000 UK BIOBANK PARTICIPANTS
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Pilling, Luke C, primary, Atkins, Janice L, additional, Bowman, Kirsty, additional, Jones, Samuel E, additional, Tyrrell, Jessica, additional, Beaumont, Robin N, additional, Ruth, Katherine S, additional, Tuke, Marcus A, additional, Yaghootkar, Hanieh, additional, Wood, Andrew R, additional, Freathy, Rachel M, additional, Murray, Anna, additional, Weedon, Michael N, additional, Xue, Luting, additional, Lunetta, Kathryn, additional, Murabito, Joanne M, additional, Harries, Lorna W, additional, Robine, Jean-Marie, additional, Brayne, Carol, additional, Kuchel, George A, additional, Ferrucci, Luigi, additional, Frayling, Timothy M, additional, and Melzer, David, additional
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- 2016
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39. A reference panel of 64,976 haplotypes for genotype imputation
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McCarthy, Shane, primary, Das, Sayantan, additional, Kretzschmar, Warren, additional, Delaneau, Olivier, additional, Wood, Andrew R., additional, Teumer, Alexander, additional, Kang, Hyun Min, additional, Fuchsberger, Christian, additional, Danecek, Petr, additional, Sharp, Kevin, additional, Luo, Yang, additional, Sidore, Carlo, additional, Kwong, Alan, additional, Timpson, Nicholas, additional, Koskinen, Seppo, additional, Vrieze, Scott, additional, Scott, Laura J., additional, Zhang, He, additional, Mahajan, Anubha, additional, Veldink, Jan, additional, Peters, Ulrike, additional, Pato, Carlos, additional, van Duijn, Cornelia M., additional, Gillies, Christopher E., additional, Gandin, Ilaria, additional, Mezzavilla, Massimo, additional, Gilly, Arthur, additional, Cocca, Massimiliano, additional, Traglia, Michela, additional, Angius, Andrea, additional, Barrett, Jeffrey, additional, Boomsma, Dorret I., additional, Branham, Kari, additional, Breen, Gerome, additional, Brummet, Chad, additional, Busonero, Fabio, additional, Campbell, Hariy, additional, Chan, Andrew, additional, Chen, Sai, additional, Chew, Emily, additional, Collins, Francis S., additional, Corbin, Laura, additional, Smith, George Davey, additional, Dedoussis, George, additional, Dorr, Marcus, additional, Farmaki, Aliki-Eleni, additional, Ferrucci, Luigi, additional, Forer, Lukas, additional, Fraser, Ross M., additional, Gabriel, Stacey, additional, Levy, Shawn, additional, Groop, Leif, additional, Harrison, Tabitha, additional, Hattersley, Andrew, additional, Holmen, Oddgeir L., additional, Hveem, Kristian, additional, Kretzler, Matthias, additional, Lee, James, additional, McGue, Matt, additional, Meitinger, Thomas, additional, Melzer, David, additional, Min, Josine, additional, Mohlke, Karen L., additional, Vincent, John, additional, Nauck, Matthias, additional, Nickerson, Deborah, additional, Palotie, Aarno, additional, Pato, Michele, additional, Pirastu, Nicola, additional, Mclnnis, Melvin, additional, Richards, Brent, additional, Sala, Cinzia, additional, Salomaa, Veikko, additional, Schlessinger, David, additional, Schoenheer, Sebastian, additional, Slagboom, P Eline, additional, Small, Kerrin, additional, Spector, Timothy, additional, Stambolian, Dwight, additional, Tuke, Marcus, additional, Tuomilehto, Jaakko, additional, Berg, Leonard Van den, additional, Van Rheenen, Wouter, additional, Volker, Uwe, additional, Wijmenga, Cisca, additional, Toniolo, Daniela, additional, Zeggini, Eleftheria, additional, Gasparini, Paolo, additional, Sampson, Matthew G., additional, Wilson, James F., additional, Frayling, Timothy, additional, Bakker, Paul de, additional, Swertz, Morris A., additional, McCarroll, Steven, additional, Kooperberg, Charles, additional, Dekker, Annelot, additional, Altshuler, David, additional, Wilier, Cristen, additional, Iacono, William, additional, Ripatti, Samuli, additional, Soranzo, Nicole, additional, Walter, Klaudia, additional, Swaroop, Anand, additional, Cucca, Francesco, additional, Anderson, Carl, additional, Boehnke, Michael, additional, McCarthy, Mark I., additional, Durbin, Richard, additional, Abecasis, Gonçalo, additional, and Marchini, Jonathan, additional
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- 2015
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40. Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause, and impact reproductive health: a UK Biobank study
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Ruth, Katherine S, primary, Beaumont, Robin N, additional, Tyrrell, Jessica, additional, Jones, Samuel E, additional, Tuke, Marcus A, additional, Yaghootkar, Hanieh, additional, Wood, Andrew R, additional, Freathy, Rachel M, additional, Weedon, Michael N, additional, Frayling, Timothy M, additional, and Murray, Anna, additional
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- 2015
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41. A reference panel of 64,976 haplotypes for genotype imputation
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Steven A. McCarroll, Gerome Breen, Nicole Soranzo, Sayantan Das, Ilaria Gandin, Lukas Forer, David Schlessinger, Jonathan Marchini, Francesco Cucca, Anand Swaroop, Seppo Koskinen, Aliki-Eleni Farmaki, Alan Kwong, Gonçalo R. Abecasis, Marcus Dörr, Yang Luo, Andrew T. Chan, Andrea Angius, P. Eline Slagboom, Petr Danecek, Cinzia Sala, Ulrike Peters, Marcus A. Tuke, D.I. Boomsma, Jan H. Veldink, Nicholas J. Timpson, Scott I. Vrieze, Aarno Palotie, Matt McGue, Wouter van Rheenen, Melvin G. McInnis, Shawn Levy, George Dedoussis, Richard Durbin, Matthias Kretzler, Ross M. Fraser, C Sidore, David Melzer, Eleftheria Zeggini, Andrew R. Wood, Veikko Salomaa, Oddgeir L. Holmen, Alexander Teumer, Hyun Min Kang, James F. Wilson, Cristen J. Willer, Laura J. Scott, Richard M. Myers, George Davey Smith, Andrew T. Hattersley, Matthias Nauck, Matthew G. Sampson, Christian Fuchsberger, Josine L. Min, Leonard H. van den Berg, Thomas Meitinger, David Altshuler, John B. Vincent, Kevin Sharp, Jaakko Tuomilehto, Daniela Toniolo, Cornelia M. van Duijn, Samuli Ripatti, Stacey Gabriel, Michael Boehnke, Annelot M. Dekker, Francis S. Collins, He Zhang, Klaudia Walter, Deborah A. Nickerson, Nicola Pirastu, Morris A. Swertz, Kari Branham, Luigi Ferrucci, Sai Chen, Fabio Busonero, Paul I.W. de Bakker, Kristian Hveem, Charles Kooperberg, Michela Traglia, Warren W. Kretzschmar, Leif Groop, Tabitha A. Harrison, Sebastian Schoenherr, J. Brent Richards, Uwe Völker, Shane A. McCarthy, Harry Campbell, Massimo Mezzavilla, Chad M. Brummett, Mark I. McCarthy, Tim D. Spector, Dwight Stambolian, Massimiliano Cocca, Emily Y. Chew, Carlos N. Pato, Jeffrey C. Barrett, Christopher E. Gillies, William G. Iacono, Karen L. Mohlke, Olivier Delaneau, Laura J Corbin, Cisca Wijmenga, Anubha Mahajan, Timothy M. Frayling, James Lee, Michele T. Pato, Carl A. Anderson, Arthur Gilly, Kerrin S. Small, Paolo Gasparini, Biological Psychology, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, McCarthy, Shane [0000-0002-2715-4187], Das, Sayantan [0000-0001-6346-1590], Kretzschmar, Warren [0000-0002-2575-0807], Durbin, Richard [0000-0002-9130-1006], Apollo - University of Cambridge Repository, Epidemiology, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Mccarthy, Shane, Das, Sayantan, Kretzschmar, Warren, Delaneau, Olivier, Wood, Andrew R, Teumer, Alexander, Kang, Hyun Min, Fuchsberger, Christian, Danecek, Petr, Sharp, Kevin, Luo, Yang, Sidore, Carlo, Kwong, Alan, Timpson, Nichola, Koskinen, Seppo, Vrieze, Scott, Scott, Laura J, Zhang, He, Mahajan, Anubha, Veldink, Jan, Peters, Ulrike, Pato, Carlo, van Duijn, Cornelia M, Gillies, Christopher E, Gandin, Ilaria, Mezzavilla, Massimo, Gilly, Arthur, Cocca, Massimiliano, Traglia, Michela, Angius, Andrea, Barrett, Jeffrey C, Boomsma, Dorrett, Branham, Kari, Breen, Gerome, Brummett, Chad M, Busonero, Fabio, Campbell, Harry, Chan, Andrew, Chen, Sai, Chew, Emily, Collins, Francis S, Corbin, Laura J, Smith, George Davey, Dedoussis, George, Dorr, Marcu, Farmaki, Aliki Eleni, Ferrucci, Luigi, Forer, Luka, Fraser, Ross M, Gabriel, Stacey, Levy, Shawn, Groop, Leif, Harrison, Tabitha, Hattersley, Andrew, Holmen, Oddgeir L, Hveem, Kristian, Kretzler, Matthia, Lee, James C, Mcgue, Matt, Meitinger, Thoma, Melzer, David, Min, Josine L, Mohlke, Karen L, Vincent, John B, Nauck, Matthia, Nickerson, Deborah, Palotie, Aarno, Pato, Michele, Pirastu, Nicola, Mcinnis, Melvin, Richards, J. Brent, Sala, Cinzia, Salomaa, Veikko, Schlessinger, David, Schoenherr, Sebastian, Slagboom, P. Eline, Small, Kerrin, Spector, Timothy, Stambolian, Dwight, Tuke, Marcu, Tuomilehto, Jaakko, van den Berg, Leonard H, van Rheenen, Wouter, Volker, Uwe, Wijmenga, Cisca, Toniolo, Daniela, Zeggini, Eleftheria, Gasparini, Paolo, Sampson, Matthew G, Wilson, James F, Frayling, Timothy, de Bakker, Paul I. W, Swertz, Morris A, Mccarroll, Steven, Kooperberg, Charle, Dekker, Annelot, Altshuler, David, Willer, Cristen, Iacono, William, Ripatti, Samuli, Soranzo, Nicole, Walter, Klaudia, Swaroop, Anand, Cucca, Francesco, Anderson, Carl A, Myers, Richard M, Boehnke, Michael, Mccarthy, Mark I, and Durbin, Richard
- Subjects
0301 basic medicine ,Netherlands Twin Register (NTR) ,Genotype ,Population ,Genome-wide association study ,Single-nucleotide polymorphism ,Computational biology ,Biology ,Polymorphism, Single Nucleotide ,SEQUENCE ,Article ,03 medical and health sciences ,0302 clinical medicine ,Reference Values ,Journal Article ,Genetics ,Humans ,GENOME-WIDE ASSOCIATION ,education ,Alleles ,POPULATION ,030304 developmental biology ,Genetic association ,Whole genome sequencing ,education.field_of_study ,Internet ,0303 health sciences ,Genotype imputation ,Medicine (all) ,Haplotype ,ALSPAC ,Minor allele frequency ,030104 developmental biology ,Genetic Techniques ,Haplotypes ,RARE VARIANTS ,030217 neurology & neurosurgery ,Imputation (genetics) ,Genome-Wide Association Study - Abstract
We describe a reference panel of 64,976 human haplotypes at 39,235,157 SNPs constructed using whole genome sequence data from 20 studies of predominantly European ancestry. Using this resource leads to accurate genotype imputation at minor allele frequencies as low as 0.1%, a large increase in the number of SNPs tested in association studies and can help to discover and refine causal loci. We describe remote server resources that allow researchers to carry out imputation and phasing consistently and efficiently.
- Published
- 2015
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