1. Developmental and Intergenerational Landscape of Human Circulatory Lipidome and its Association with Obesity Risk
- Author
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A-L Ponsonby, Yung Seng Lee, David Burgner, Johan G. Eriksson, Peter J. Meikle, Bo Burla, Sartaj Ahmad Mir, Fiona Collier, Richard Saffery, Li Chen, Corey Giles, Smith Aat, Anne K. Bendt, Gerard Wong, Mei D, Neerja Karnani, Kevin Huynh, Shanshan Ji, Peter D. Gluckman, Y.S. Chong, Kok Hian Tan, Fabian Yap, Satvika Burugupalli, Kothandaraman Narasimhan, Peter Vuillermin, Karen Mei Ling Tan, Adaikalavan Ramasamy, and Markus Rennie Wenk
- Subjects
Offspring ,Lipid composition ,Cord blood ,Circulatory system ,Gestation ,Physiology ,lipids (amino acids, peptides, and proteins) ,Obesity risk ,Lipidome ,Biology ,Early life - Abstract
Lipids play a vital role in human health and development, but changes to their circulatory levels during gestation and in early life are poorly understood. Here we present the first developmental and intergenerational landscape of the human circulatory lipidome, derived by profiling of 480 lipid species representing 25 lipid classes, in mothers and their offspring (n=2491). Levels of 66% of the profiled lipids increased in maternal circulation during gestation, while cord blood had higher concentrations of acylcarnitines and lysophospholipids. The offspring lipidome at age six years revealed striking similarities with postnatal maternal lipidome (adult) in its lipid composition and concentrations. Comparison of lipids associated with child and maternal adiposity identified a 92% overlap, implying intergenerational similarities in the lipid signatures of obesity risk. We also catalogued lipid signatures linked with maternal adiposity during gestation and offspring birthweight, and validated (>70% overlap) the findings in an independent birth-cohort (n=1935).
- Published
- 2021
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