1. Precautions are Needed for COVID-19 Patients with Coinfection of Common Respiratory Pathogens
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Wenjie Li, Silin Pan, Yang Gao, Kai Deng, Guoju Li, Qin Wu, Ai Zhang, Zi-pu Li, Chang-zheng Chen, Ruqin Gao, Yue Sun, Quansheng Xing, Jianning Tong, Ting Chen, Qiang Li, Gui-liang Hao, Wei Li, Guiling Yu, Wei Ni, and Yuhan Xing
- Subjects
Mycoplasma pneumoniae ,medicine.medical_specialty ,biology ,business.industry ,Outbreak ,medicine.disease ,medicine.disease_cause ,Virus ,Respiratory pathogens ,Pneumonia ,Informed consent ,Internal medicine ,Epidemiology ,biology.protein ,Coinfection ,medicine ,Respiratory system ,Antibody ,business ,Coronavirus - Abstract
Background: With the ongoing outbreak of Coronavirus Disease 2019 (COVID-19), infected patients within and beyond the epidemic area, Wuhan, China, showed different epidemiological and clinical characteristics. Little is known about the pattern of coinfection with other common respiratory pathogens in COVID-19 patients outside of Wuhan. Methods: We conducted a double-centre study recruiting 68 patients with severe acute respiratory coronavirus 2 (SARS-CoV-2) infection confirmed by nucleic acid testing in Qingdao and Wuhan from January 17 to February 16, 2020. Indirect immuno-fluorescence was performed to detect the specific IgM antibody against common respiratory pathogens in collected acute phase serum. Findings: Of the 68 patients with SARS-CoV-2 infection, 30 (44.12%) were from Qingdao. The median age of Qingdao and Wuhan patients were 50 (IQR: 37-59) and 31 (IQR: 28-38) years, respectively, and the majority of patients were female in Qingdao (60.00%) and Wuhan (55.26%). Among COVID-19 patients in Qingdao, 24 (80.00%) of them had IgM antibodies against at least one respiratory pathogen, whereas only one (2.60%) of the patients in Wuhan had positive results for serum IgM antibody detection ( P
- Published
- 2020
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