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Your search keyword '"Liu, Ting-Hsiu"' showing total 1 results
Start Over Author "Liu, Ting-Hsiu" Publisher cold spring harbor laboratory press
1 results on '"Liu, Ting-Hsiu"'

1. Association of Chk1 with 14-3-3 proteins is stimulated by DNA damage

Author

Chen, Lin, Liu, Ting-Hsiu, and Walworth, Nancy C.

Subjects
Proteins -- Research, Genetic research -- Analysis, Cell cycle -- Research, DNA -- Research, Phosphorylation -- Research, Biological sciences
Abstract

DNA damage-dependent links between phosphorylated Chk1 and 14-3-3 proteins suggest these mediate a significant step on the DNA-damage checkpoint path. The 14-3-3 proteins Rad24 and Rad25 interact with Chk1 in fission yeast. Once DNA is damaged, Chk1 is phosphorylated and the 14-3-3 proteins prefer binding to that form. In fission yeast, the interaction between 14-3-3 proteins and Cdc25 does not require Chk1 function.

Published
1999

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