Search

Your search keyword '"Sayaka Sekine"' showing total 2 results
Start Over Author "Sayaka Sekine" Publisher cold spring harbor laboratory press
2 results on '"Sayaka Sekine"'

1. Dendritic Eph organizes dendrodendritic segregation in discrete olfactory map formation in Drosophila

Author

Marie Anzo, Kinhong Chao, Masayuki Miura, Takahiro Chihara, Sayaka Sekine, and Shirin Makihara

Subjects
0301 basic medicine, Olfactory system, Dendrite, Biology, Olfactory Receptor Neurons, 03 medical and health sciences, Genetics, medicine, Ephrin, Animals, Drosophila Proteins, Glomerulus (olfaction), Olfactory receptor, Receptor, EphA1, Gene Expression Profiling, Erythropoietin-producing hepatocellular (Eph) receptor, Gene Expression Regulation, Developmental, Membrane Proteins, Dendrites, biological factors, 030104 developmental biology, medicine.anatomical_structure, Drosophila melanogaster, nervous system, Gene Knockdown Techniques, Axon guidance, Antennal lobe, RNA Interference, sense organs, biological phenomena, cell phenomena, and immunity, Neuroscience, Developmental Biology, Research Paper
Abstract

Proper function of the neural network results from the precise connections between axons and dendrites of presynaptic and postsynaptic neurons, respectively. In the Drosophila olfactory system, the dendrites of projection neurons (PNs) stereotypically target one of ∼50 glomeruli in the antennal lobe (AL), the primary olfactory center in the brain, and form synapses with the axons of olfactory receptor neurons (ORNs). Here, we show that Eph and Ephrin, the well-known axon guidance molecules, instruct the dendrodendritic segregation during the discrete olfactory map formation. The Eph receptor tyrosine kinase is highly expressed and localized in the glomeruli related to reproductive behavior in the developing AL. In one of the pheromone-sensing glomeruli (DA1), the Eph cell-autonomously regulates its dendrites to reside in a single glomerulus by interacting with Ephrins expressed in adjacent PN dendrites. Our data demonstrate that the trans interaction between dendritic Eph and Ephrin is essential for the PN dendritic boundary formation in the DA1 olfactory circuit, potentially enabling strict segregation of odor detection between pheromones and the other odors.

Published
2017

2. Dendritic Eph organizes dendrodendritic segregation in discrete olfactory map formation in Drosophila.

Author

Anzo, Marie, Sayaka Sekine, Shirin Makihara, Kinhong Chao, Masayuki Miura, and Takahiro Chihara

Subjects
*DENDRITIC cells, *DENDRITES, *AXONS, *DROSOPHILA, *OLFACTORY cortex, *NEURONS, *SYNAPSES
Abstract

Proper function of the neural network results from the precise connections between axons and dendrites of presynaptic and postsynaptic neurons, respectively. In the Drosophila olfactory system, the dendrites of projection neurons (PNs) stereotypically target one of ~50 glomeruli in the antennal lobe (AL), the primary olfactory center in the brain, and form synapses with the axons of olfactory receptor neurons (ORNs). Here, we show that Eph and Ephrin, the well-known axon guidance molecules, instruct the dendrodendritic segregation during the discrete olfactory map formation. The Eph receptor tyrosine kinase is highly expressed and localized in the glomeruli related to reproductive behavior in the developing AL. In one of the pheromone-sensing glomeruli (DA1), the Eph cell-autonomously regulates its dendrites to reside in a single glomerulus by interacting with Ephrins expressed in adjacent PN dendrites. Our data demonstrate that the trans interaction between dendritic Eph and Ephrin is essential for the PN dendritic boundary formation in the DA1 olfactory circuit, potentially enabling strict segregation of odor detection between pheromones and the other odors. [ABSTRACT FROM AUTHOR]

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results