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Background: The global prevalence of allergic rhinitis is high. International Study of Asthma and Allergies in Childhood (ISAAC) Phase III reports a total estimated prevalence of 4.6% in Mexico. There is evidence based on allergic rhinitis Clinical Practice Guidelines (CPG), but its promotion, acceptance and application is not optimal or adequate in Mexico. Objective: To generate a guideline for the treatment of allergic rhinitis and its impact on asthma by adaptating the 2010 ARIA Guideline to Mexican reality, through a transculturation process applying the ADAPTE methodology. Material and method: Using the ADAPTE Methodology, the original 2010 ARIA CPG recommendations were evaluated by the guideline development group (GDG) into which multiple medical specialities managing patients with allergic rhinitis were incoorporated. The GDG valorated the quality of 2010 ARIA, checked and translated key clinical questions. Moreover, the GDG adjusted recommendations, patient preferences and included comments in the context of the Mexican reality (safety, costs and cultural issues). To accomplish this, we ran Delphi panels with as many rounds as necessary to reach agreement. One extra question, not included in the original 2010 ARIA, on the use of Nasal Lavages for AR was created sustained by a systematic literature review. Results: A total of 45 questions from the original 2010 ARIA were included and divided into six groups covering prevention, medical treatment, immunotherapy and alternative medicine to treat patients with allergic rhinitis with or without asthma. Most of the questions reached agreement in one or two rounds; one question required three rounds. Conclusions: An easy-to-use, adaptated, up-to-date and applicable allergic rhinitis guideline for Mexico is now available.

Background: Allergic conjunctivitis is an in ammatory disease which involves the conjunctiva, its physiopathology is a type I hypersensitivity (IgE mediated). It is related to the sensitization to indoors and out- doors aeroallergens. Clinically it is classi ed as seasonal or perennial. It presents as ocular pruritus, conjunctival hyperemia, epiphora and photophobia. Objective: To determine the frequency of sensitization to aeroallergens in patients with allergic conjunctivitis, seasonal and perennial, who attend the Allergy and Clinical Immunology Department at Mexican General Hospital Dr. Eduardo Liceaga. Material and method: A transversal and descriptive study was made in patients with seasonal and perennial allergic conjunctivitis. After in- formed consent, we obtained a complete clinical evaluation, laboratory studies and skin tests for aeroallergens. We determined the frequency of sensitization to those aeroallergens. Results: We found sensitization most frequently to pollens such as Quercus, Alnus and Fraxinus, followed by Dermatophagoides spp. We had predominantly female patients of the second and fourth decades of life. Conclusions: Allergic conjunctivitis is a pathology frequently associated with allergic rhinitis. The most frequently involved allergens in this study were pollens and house dust mite.