1. Oncogenic cooperation between Yorkie and the conserved microRNA miR-8 in the wing disc of Drosophila .
- Author
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Sander M, Eichenlaub T, and Herranz H
- Subjects
- Animals, Drosophila, Drosophila Proteins genetics, Hematologic Neoplasms embryology, Hematologic Neoplasms genetics, MicroRNAs genetics, Nuclear Proteins genetics, Oncogene Proteins genetics, Repressor Proteins genetics, Trans-Activators genetics, YAP-Signaling Proteins, Drosophila Proteins biosynthesis, Gene Expression Regulation, Developmental, Imaginal Discs embryology, MicroRNAs biosynthesis, Nuclear Proteins biosynthesis, Oncogene Proteins biosynthesis, Repressor Proteins biosynthesis, Trans-Activators biosynthesis
- Abstract
Tissue growth has to be carefully controlled to generate well-functioning organs. MicroRNAs are small non-coding RNAs that modulate the activity of target genes and play a pivotal role in animal development. Understanding the functions of microRNAs in development requires the identification of their target genes. Here, we find that miR-8 , a conserved microRNA in the miR-200 family, controls tissue growth and homeostasis in the Drosophila wing imaginal disc. Upregulation of miR-8 causes the repression of Yorkie , the effector of the Hippo pathway in Drosophila , and reduces tissue size. Remarkably, co-expression of Yorkie and miR-8 causes the formation of neoplastic tumors. We show that upregulation of miR-8 represses the growth inhibitor brinker , and depletion of brinker cooperates with Yorkie in the formation of neoplastic tumors. Hence, miR-8 modulates a positive growth regulator, Yorkie , and a negative growth regulator, brinker Deregulation of this network can result in the loss of tissue homeostasis and the formation of tumors., Competing Interests: Competing interestsThe authors declare no competing or financial interests., (© 2018. Published by The Company of Biologists Ltd.)
- Published
- 2018
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