1. Model systems for regeneration: Hydra .
- Author
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Vogg MC, Galliot B, and Tsiairis CD
- Subjects
- Animals, Gene Editing, Gene Silencing, Homeostasis, Organoids, Phylogeny, Signal Transduction, Stem Cells cytology, Transgenes, Wnt Proteins metabolism, beta Catenin metabolism, Gene Expression Regulation, Developmental, Hydra cytology, Hydra physiology, Models, Biological, Regeneration physiology
- Abstract
The freshwater polyp Hydra provides a potent model system for investigating the conditions that promote wound healing, reactivation of a developmental process and, ultimately, regeneration of an amputated body part. Hydra polyps can also be dissociated to the single cell level and can regenerate a complete body axis from aggregates, behaving as natural organoids. In recent years, the ability to exploit Hydra has been expanded with the advent of new live-imaging approaches, genetic manipulations that include stable transgenesis, gene silencing and genome editing, and the accumulation of high-throughput omics data. In this Primer, we provide an overview of Hydra as a model system for studying regeneration, highlighting recent results that question the classical self-enhancement and long-range inhibition model supposed to drive Hydra regeneration. We underscore the need for integrative explanations incorporating biochemical as well as mechanical signalling., Competing Interests: Competing interestsThe authors declare no competing or financial interests., (© 2019. Published by The Company of Biologists Ltd.)
- Published
- 2019
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