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1 results on '"Chlorthalidone chemistry"'

1. The control of impurities in chlortalidone using a reversed-phase stationary phase.

Author

Douville V, Keller E, Lambertz K, Lodi A, and Miller JH

Subjects
Antihypertensive Agents analysis, Antihypertensive Agents chemistry, Chlorthalidone chemistry, Drug Stability, Molecular Structure, Reproducibility of Results, Chlorthalidone analysis, Chromatography, High Pressure Liquid methods, Drug Contamination prevention & control
Abstract

A reversed-phased liquid chromatographic method for the control of impurities of nine impurities in Chlortalidone drug substance is presented. The method is sufficiently sensitive to quantify down to the level of 0.0015 per cent equivalent to a concentration of 15 microg/ml.

Published
2005

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