1. Sympathovagal balance and 1-h postload plasma glucose in normoglucose tolerant hypertensive patients
- Author
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Paola Elisa Scarpino, Serena Di Cello, Michele Andreucci, Angela Sciacqua, Maria Perticone, Desirée Addesi, Paola Naccarato, Francesco Perticone, Raffaele Maio, Anna Licata, Salvatore Carrao, Giorgio Sesti, Eliezer J. Tassone, and Perticone M, Tassone EJ, Scarpino PE, Naccarato P, Addesi D, di Cello S, Sciacqua A, Maio R, Andreucci M, Corrao S, Licata A, Sesti G, Perticone F.
- Subjects
Adult ,Blood Glucose ,Male ,medicine.medical_specialty ,Settore MED/09 - Medicina Interna ,endocrine system diseases ,glucose tolerance ,Insulin resistance Heart rate variability Glucose tolerance Essential hypertension ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,030209 endocrinology & metabolism ,030204 cardiovascular system & hematology ,Essential hypertension ,Autonomic Nervous System ,insulin resistance, heart rate variability, glucose tolerance, essential hypertension ,Impaired glucose tolerance ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Insulin resistance ,Heart Rate ,Internal medicine ,Diabetes mellitus ,insulin resistance ,Glucose Intolerance ,Internal Medicine ,Medicine ,Heart rate variability ,Homeostasis ,Humans ,Subclinical infection ,Balance (ability) ,Aged ,business.industry ,Insulin ,heart rate variability ,essential hypertension ,nutritional and metabolic diseases ,General Medicine ,Glucose Tolerance Test ,Middle Aged ,medicine.disease ,Diabetes Mellitus, Type 2 ,Hypertension ,Cardiology ,Female ,business ,hormones, hormone substitutes, and hormone antagonists - Abstract
AIMS: Normoglucose tolerant (NGT) subjects with a 1-h postload plasma glucose (PLPG) value ≥155 mg/dL have an increased risk of type-2 diabetes and subclinical organ damage. Heart rate variability (HRV) reflects cardiac autonomic balance, frequently impaired in course of diabetes. At this time, no data support the association between 1-h PLPG and HRV; thus, we investigated the possible association between 1-h PLPG and HRV. METHODS: We enrolled 92 never-treated hypertensive subjects (56 women, 36 men), aged 55 ± 9.8 years. During OGTT, the patients underwent electrocardiographic recordings to evaluate HRV in the time domain (SDNN). Insulin sensitivity was assessed by Matsuda index. RESULTS: Among participants, 56 were NGT, 20 had impaired glucose tolerance (IGT), and 16 had type-2 diabetes. According to the 1-h PLPG cutoff point of 155 mg/dL, we divided NGT subjects into: NGT < 155 (n = 38) and NGT ≥ 155 (n = 18). Glucose tolerance status was associated with a significant (P < 0.0001) increase in PLPG and insulin and the reduction in Matsuda index. In all groups, the SDNN values significantly (P < 0.0001) decreased during the first hour of OGTT. A complete recovery in NGT groups was observed at the end of the second hour; in IGT and type-2 diabetes, SDNN remained significantly lower with respect to baseline values. At multiple regression analysis, Matsuda index resulted in the only determinant of SDNN modification, explaining the 12.3 % of its variability. CONCLUSIONS: Our data demonstrate that during OGTT, sympathovagal balance is acutely affected by both glucose and insulin modifications. Particularly, NGT ≥ 155 subjects behave in the same way of IGT and type-2 diabetes patients.
- Published
- 2015