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Global temperatures are rising, and concerns about the response of agricultural production to climate change are increasing. Adaptation is a key factor that will shape the severity of impacts of future climate change on food production. Based on actual meteorological, soil and agricultural management data at site scale, the CERES-Rice model, combined with the Regional Climate Model (RCM)-PRECIS, was used to simulate both the effects of climate change on rice yields and the efficacy of adaptive options in Northeast China. The impact simulation showed that rice yield changes ranged from +0.1% to –44.9% (A2 scenario) and from –0.3% to –40.1% (B2 scenario) without considering CO2 fertilisation effects. When considering CO2 fertilisation effects, rice yield reductions induced by temperature increases were decreased at all sites. The CO2 fertilisation effects may partly offset the negative impacts of climate change on rice yields. Adaptive option results revealed that the adverse impacts of climate change on rice yields could be mitigated by advancing the planting dates, transplanting mid–late-maturing rice cultivars to replace early-maturing ones, and breeding new rice cultivars with high thermal requirements. Our findings provide insight into the possible impacts of climate change on rice production, and we suggest which adaptive strategies could be used to cope with future climate change, thus providing evidence-based suggestions for government policy on adaptive strategies.