1. Medical Management of Heparin-Induced Thrombocytopenia Causing Acute Adrenal Insufficiency
- Author
-
W. Kalaji, L.N. Gerolemou, Mudita Patel, Jad Sargi, and Samridhi Sinha
- Subjects
medicine.medical_specialty ,030204 cardiovascular system & hematology ,Argatroban ,03 medical and health sciences ,0302 clinical medicine ,Heparin-induced thrombocytopenia ,Internal medicine ,Antithrombotic ,Adrenal insufficiency ,Internal Medicine ,Medicine ,Thrombus ,business.industry ,General Engineering ,Endocrinology/Diabetes/Metabolism ,Heparin ,Hematology ,medicine.disease ,Discontinuation ,Venous thrombosis ,Cardiology ,heparin-induced thrombocytopenia ,business ,adrenal insufficiency ,immune mediated phenomenon ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Heparin-induced thrombocytopenia is an immune-mediated reaction to heparin and heparin analogs, which results in an acquired hypercoagulability syndrome resulting in paradoxical arterial and venous thrombosis leading to thrombocytopenia. Organs with high vascularity, such as the adrenal glands, are at an increased risk of injury in heparin-induced thrombocytopenia due to thrombus formation in the adrenal vein causing adrenal insufficiency. The standard of treatment remains discontinuation of heparin and heparin analogs and starting corticosteroids and non-heparin antithrombotic therapy such as argatroban.
- Published
- 2021