1. Serotonin Selective Reuptake Inhibitors (SSRIs) and Stroke.
- Author
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Chollet F, Rigal J, Marque P, Barbieux-Guillot M, Raposo N, Fabry V, Albucher JF, Pariente J, and Loubinoux I
- Subjects
- Depression drug therapy, Humans, Recovery of Function drug effects, Stroke physiopathology, Selective Serotonin Reuptake Inhibitors therapeutic use, Stroke drug therapy
- Abstract
Purpose of Review: The interest in SSRIs after stroke has increased in the past few years, with better knowledge of post-stroke depression and with the demonstrated capacity of some SSRIs to act on the functional recovery of non-depressed subjects., Recent Findings: Arguments for the action of SSRIs in favour of post-stroke neurological function recovery have improved through new elements: basic science and preclinical data, positive clinical trials and repeated series of stroke patient meta-analysis, and confirmation of favourable safety conditions in post-stroke patients. Global coherence is appearing, showing that SSRIs improve stroke recovery in non-depressed patients when given for 3 months after the stroke, with highly favourable safety conditions and a favourable benefit/risk ratio. Large series are still needed.
- Published
- 2018
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