1. NEUROLEPTICKÝ MALIGNÍ SYNDROM A JEHO ŘEŠENÍ V KLINICKÉ PRAXI Z PERSPEKTIVY SOUČASNÝCH DOPORUČENÝCH POSTUPŮ.
- Author
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Češková, Eva and Horská, Kateřina
- Subjects
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NEUROLEPTIC malignant syndrome , *MEDICAL personnel , *ELECTROCONVULSIVE therapy , *AUTONOMIC nervous system , *PRIMARY care - Abstract
The paper deals with recent aspects of diagnosis and treatment of neuroleptic malignant syndrome (NMS). NMS is an antipsychotic-induced, life-threatening condition, characterized by hyperpyrexia, muscle rigidity, qualitative alteration of consciousness and autonomic nervous system dysregulation. NMS prevalence and mortality rates have declined over the past 30 years, most likely due to early recognition of the syndrome and appropriate intervention. Recent reports suggest a prevalence of 0.02-0.03%, and 5.6% mortality. Treatment includes withdrawal of the offending dopamine antagonist, supportive care and may include the use of specific pharmacotherapies (benzodiazepines, bromocriptine, amentadine, dantrolene) and electroconvulsive therapy. Nonetheless, clinicians, especially primary care clinicians who are using antipsychotics more often for adjunctive treatments, must be cognizant of this syndrome. [ABSTRACT FROM AUTHOR]
- Published
- 2021