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1. Multicentric giant cell tumor with viral-like inclusions associated with Paget's disease of bone: a case treated by steroid therapy.

Author

De Chiara A, Apice G, Fazioli F, Silvestro P, Carone G, and Manco A

Subjects
Cell Nucleus ultrastructure, Cell Nucleus virology, Giant Cell Tumor of Bone drug therapy, Giant Cell Tumor of Bone pathology, Giant Cell Tumor of Bone virology, Giant Cells pathology, Humans, Male, Middle Aged, Skull Neoplasms drug therapy, Skull Neoplasms pathology, Skull Neoplasms virology, Tomography, X-Ray Computed, Giant Cell Tumor of Bone complications, Glucocorticoids therapeutic use, Inclusion Bodies, Viral ultrastructure, Osteitis Deformans complications, Prednisolone therapeutic use, Skull Neoplasms complications
Abstract

We report a case of giant cell tumor of bone (GCTB) associated with Paget's disease unsuccefully treated with radiotherapy for some years but dramatically reduced in size with high dose of dexamethasone within few days. An ultrastructural study showed intranuclear virus-like inclusions in the multinucleated giant cells. The patient was then switched to prednisone plus diclofenac and he is still in almost complete remission after two years. The patient was from Avellino area, a small town in Southern Italy.

Published
1998

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