1. Association of xeroderma pigmentosum complementation group G Asp1104His polymorphism with breast cancer risk: A cumulative meta-analysis
- Author
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Yu‑Ming Niu, Jian‑Qiang Jin, Xiao‑Ming Xu, Xiao‑Li Hu, Long‑Chuan Xie, and Ling‑Ling Yuan
- Subjects
Oncology ,Cancer Research ,education.field_of_study ,medicine.medical_specialty ,Xeroderma pigmentosum ,Oncogene ,business.industry ,Population ,Subgroup analysis ,Odds ratio ,Articles ,medicine.disease ,Bioinformatics ,Breast cancer ,Internal medicine ,Meta-analysis ,Medicine ,business ,education ,Nucleotide excision repair - Abstract
The xeroderma pigmentosum complementation group G (XPG) gene plays an important role in the DNA nucleotide excision repair (NER) pathway. Several studies have investigated the association between the XPG Asp1104His polymorphism and breast cancer; however, the results have been inconsistent. Therefore, we conducted a meta-analysis of 8 published articles (10 case-control studies) including a total of 5,235 patients with breast cancer and 5,685 healthy controls. The results demonstrated that the XPG Asp1104His polymorphism was not associated with breast cancer in the overall population [His vs. Asp, odds ratio (OR)=1.00, 95% confidence interval (CI): 0.91-1.08; His/His vs. Asp/Asp, OR=0.96, 95% CI: 0.83-1.11; Asp/His vs. Asp/Asp, OR=1.02, 95% CI: 0.94-1.11; His/His+Asp/His vs. Asp/Asp, OR=1.03, 95% CI: 0.92-1.15; and His/His vs. Asp/Asp+Asp/His, OR=0.93, 95% CI: 0.81-1.06]. In the subgroup analysis by ethnicity, no significant association was observed in European subjects. In conclusion, this meta-analysis suggested that the XPG Asp1104His polymorphism is not associated with breast cancer risk.
- Published
- 2014