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Due to signal shielding caused by building structures, conventional mature positioning technologies such as the Global Positioning System (GPS) are only suitable for outdoor navigation and detection. However, there are many scenarios that urgently require high-precision indoor positioning technologies, such as indoor wireless optical communications (OWCs), navigation in large buildings, and warehouse management. Here, we proposed a millimeter-precision indoor positioning technology based on metalens-integrated camera, which determines the position of the device through imaging of beacon LEDs. Thanks to the wide-angle imaging design of our metalens, the camera can accurately capture images of beacon LEDs even when it is situated in distant corner locations. Consequently, our localization scheme achieves millimeter-level positioning accuracy across majority of wide-angle (∼120°) indoor area. Compared to traditional positioning schemes by photodiode (PD), our imaging-based approach demonstrates superior resistance to interference, thereby safeguarding positioning precision from the external signals influence. Furthermore, the compact dimensions and high performances of the positioning device make it suitable for integration into highly portable devices, such as smartphones and drones, revealing its broad potential applications in the future. [ABSTRACT FROM AUTHOR]

Optical phased array (OPA), as a promising beam steering technology, however, usually suffers from a narrow field of view (FOV) that limits its performances in applications. A miniaturized compact strategy to enlarge the beam steering angle is quite desirable for the solid-state OPA technique. Here an on-chip metasurface-doublet is proposed to offer angle magnification integrated with a port-selected optical phased array. It is implemented by combing convex and concave metalenses with the quadratic phase distribution, which is precisely integrated on the OPA chip by layer-by-layer fabrication process. Here, the OPA is fabricated in Lithium Niobate on Insulator (LNOI) platform. Our experiments show that the metasurface-doublet is able to achieve 1.54 times FOV amplification in a horizontal direction and with >41% working efficiency. Our results provide a feasible approach to achieve enlarged FOV for wide-angle beam steering and also imply a powerful platform in developing integrated multilayer metasurface devices. [ABSTRACT FROM AUTHOR]

Since December, 2019, Wuhan, China, has experienced an outbreak of coronavirus disease 2019 (COVID-19). We conducted a retrospective study of COVID-19 inpatients in Wuhan Pulmonary Hospital (Wuhan, China) from January 1 to February 29, 2020. The subjects were divided into four groups due to different treatment regimes. We used the Kaplan–Meier method to determine the cumulative rates of in-hospital death and the Cox proportional hazard model to calculate the risk factors and corresponding hazard ratios. A total of 185 patients were included in this study. The median age of the patients was 62 years, including 94 men and 91 women. Kaplan–Meier analysis demonstrated that mortality was higher in older patients, higher in men, and lower in the low-flow oxygen therapy group. Body mass-index (BMI) had no influence on mortality, as well as high flow oxygen therapy, Lopinavir–ritonavir (LPV/r) therapy, and the interferon-alpha add LPV/r therapy. Cox proportional hazard regression confirmed that the low flow oxygen therapy was independent protective factor for in-hospital death after adjusting for age, gender, and BMI. In conclusion, the mortality was higher in older patients, higher in men, and lower in the low-flow oxygen therapy group. BMI had no influence on mortality, as well as high flow oxygen therapy, LPV/r therapy, and interferon-alpha add LPV/r therapy. [ABSTRACT FROM AUTHOR]

Background ‒ Cutaneous melanoma is an aggressive cancer with increasing incidence and mortality rates worldwide. Metastasis is one of the primary elements that influence the prognosis of patients with cutaneous melanoma. This study aims to clarify the potential mechanism underlying the low survival rate of metastatic melanoma and to search for novel target genes to improve the survival rate of patients with metastatic tumors. Methods ‒ Gene expression dataset and clinical data were downloaded from The Cancer Genome Atlas portal. Differentially expressed genes (DEGs) were identified, and their functions were studied through gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses. Survival and multivariate Cox regression analyses were used to screen out candidate genes that could affect the prognosis of patients with metastatic melanoma. Results ‒ After a series of comprehensive statistical analysis, 464 DEGs were identified between primary tumor tissues and metastatic tissues. Survival and multivariate Cox regression analyses revealed four vital genes, namely, POU2AF1, ITGAL, CXCR2P1, and MZB1, that affect the prognosis of patients with metastatic melanoma. Conclusion ‒ This study provides a new direction for studying the pathogenesis of metastatic melanoma. The genes related to cutaneous metastatic melanoma that affect the overall survival time of patients were identified. [ABSTRACT FROM AUTHOR]

C22H14Cu2N4O7, monoclinic, P21/n (no. 14), a = 7.7885(4) Å, b = 14.9974(8) Å, c = 17.7464(10) Å, β = 102.184(2)°, V = 2026.22(19) Å3, Z = 4, Rgt(F) = 0.0357, wRref(F2) = 0.0936, T = 300(2) K. [ABSTRACT FROM AUTHOR]

Photothermal therapy (PTT) of nanomaterials is an emerging novel therapeutic strategy for breast cancer. However, there exists an urgent need for appropriate strategies to enhance the antitumor efficacy of PTT and minimize damage to surrounding normal tissues. Piezo1 might be a promising novel photothermal therapeutic target for breast cancer. This study aims to explore the potential role of Piezo1 activation in the hyperthermia therapy of breast cancer cells and investigate the underlying mechanisms. Results showed that the specific agonist of Piezo1 ion channel (Yoda1) aggravated the cell death of breast cancer cells triggered by heat stress in vitro. Reactive oxygen species (ROS) production was significantly increased following heat stress, and Yoda1 exacerbated the rise in ROS release. GSK2795039, an inhibitor of NADPH oxidase 2 (NOX2), reversed the Yoda1-mediated aggravation of cellular injury and ROS generation after heat stress. The in vivo experiments demonstrate the well photothermal conversion efficiency of TiCN under the 1,064 nm laser irradiation, and Yoda1 increases the sensitivity of breast tumors to PTT in the presence of TiCN. Our study reveals that Piezo1 activation might serve as a photothermal sensitizer for PTT, which may develop as a promising therapeutic strategy for breast cancer.

Epidemiological and clinical characteristics of patients with COVID-19 have been reported in the last two years. A few studies reported clinical course of illness of median 22 days, including viral shedding of median 20 days, but there are several cases with a longer time of viral shedding. In this study, we included four cases with a longer illness course of more than 40 days who had been discharged or still in hospital by March 15, 2020. Demographic, clinical treatment, and laboratory data, including serial samples for viral RNA detection, were extracted from electronic medical records. We described the epidemiological and clinical characteristics and the course of viral shedding. Two patients had comorbidity, one with hypertension and the other with diabetes. We found smoking was not an independent risk factor. D-dimer maybe related to the severity of illness but not to the course of the illness. Nucleic acid detection suggested that maybe more sampling sites represented more virus replication sites and longer course of illness. In this study we found some non-critical severe relatively young patients whose character was different from former studies described to provide a basis for reference to assess the risk of transmission and the isolation duration of patients.