1. Novel tetrazole PtII and PdII complexes with enhanced water solubility: synthesis, structural characterization and evaluation of antiproliferative activity.
- Author
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Serebryanskaya, Tatiyana V., Lyakhov, Alexander S., Ivashkevich, Ludmila S., Grigoriev, Yuri V., Kritchenkov, Andreii S., Khrustalev, Victor N., Tskhovrebov, Alexander G., and Ivashkevich, Oleg A.
- Subjects
TETRAZOLES ,HIGH performance liquid chromatography ,SOLUBILITY ,MOLECULAR structure ,NUCLEAR magnetic resonance ,MOLECULAR crystals - Abstract
Novel platinum(II) and palladium(II) chlorido complexes with tetrazole derivatives 1-(2-hydroxyethyl)tetrazole (het) and 1-[tris(hydroxymethyl)methyl]tetrazole (thm), viz. cis-[Pt(het)
2 Cl2 ], trans-[Pt(het)2 Cl2 ], trans-[Pt(thm)2 Cl2 ], trans-[Pd(het)2 Cl2 ], and trans-[Pd(thm)2 Cl2 ], were synthesized. The compounds were characterized by elemental and high-resolution electrospray ionization (HRESI) mass spectrometry, high-performance liquid chromatography (HPLC),1 H,13 C and195 Pt nuclear magnetic resonance (NMR) spectroscopy, thermal analyses, and Infrared (IR) spectroscopy. Molecular and crystal structures of trans-[PdL2 Cl2 ] and trans-[PtL2 Cl2 ] (L = het, thm) were established by single-crystal X-ray analysis. The complex cis-[Pt(het)2 Cl2 ] was found to undergo cis–to–trans isomerization upon heating in acetonitrile solution and in the solid state. The synthesized complexes show rather high water solubility lying in the range of 2–10 mg/L. [ABSTRACT FROM AUTHOR]- Published
- 2021
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