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1. Does carbamazepine-epoxide conjugate with glutathione? On an existing but almost forgotten possibility.

Author

Kalapos MP, Debreczeni J, Széll K, Olajos S, and Herczeg I

Subjects
Anticonvulsants therapeutic use, Carbamazepine therapeutic use, Child, Child Behavior Disorders drug therapy, Epoxy Compounds blood, Female, Humans, Anticonvulsants blood, Carbamazepine blood, Cystinuria blood, Glutathione blood
Abstract

The anticonvulsant carbamazepine is widely used to treat affective disorders and behavioural disorders in non-epileptic children. We report an elevated plasma level of carbamazepine-10,11-epoxide in a cystinuric child after daily medication with 300 mg carbamazepine while the serum level of carbamazepine was in the therapeutic range. The concentrations of carbamazepine and its epoxide derivative were determined by HPLC. The formation of a glutathione conjugate of carbamazepine-10,11-epoxide is raised as a hypothesis.

Published
2000
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