The present study deals with a microwave-assisted oxidation roasting oxide–sulphide zinc ore technology of with addition of manganese dioxide. Effects of roasting parameters such as MnO2 addition level, roasting temperature, and holding time are studied by using the Central Composite Design (CCD). Meanwhile, zinc calcines are characterized by phase compositions analyses(XRD), structure characteristics of minerals (FT-IR), micro-area chemical analyses (SEM-EDAX) and elemental valence bonding analyses (XPS), which prove to be in accordance with the CCD results. The optimum roasting conditions are decided as MnO2 addition level being 85.14 %, roasting temperature 680 °C, and holding time 41 mins, and oxidation degree of zinc can reach 88.22 %. Besides, when MnO2 addition level reaches a certain value, zinc will aggregate in a form of ZnMn2O4, one battery material.