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The hydrodynamic flow of an incompressible and isotropic Casson fluid through a yawed cylinder is investigated by employing continuity, momentum, and energy equations satisfying suitable boundary conditions. The density variation is governed by Boussinesq approximation. The model equations consisting of coupled partial differential equations (PDEs) are transformed by applying non-similar transformation relations. The set of transformed PDEs is solved using the analytical technique of homotopy analysis method (HAM). The impacts of varying yaw angle, and mixed convection and Casson parameters over fluid velocity (chordwise and spanwise components), its temperature, Nusselt number, and skin friction coefficients are investigated and explained through various graphs. It is found that the enhancing yaw angle, Casson parameter, and convection parameter augment the fluid velocity, heat transfer rate, and skin friction and reduce the fluid temperature. The agreement of present and published results justifies the application of HAM in modeling the mixed convective Casson fluid flow past a yawed cylinder.