1. [Effects of glucagon-like peptides on gallbladder motility].
- Author
-
Gether IM, Nexøe-Larsen C, Sonne DP, and Knop FK
- Subjects
- Bile Acids and Salts, Cholecystokinin, Humans, Gallbladder physiology, Glucagon-Like Peptide 1 physiology
- Abstract
As cases of gallbladder-related adverse events have been reported in patients treated with glucagon-like peptide (GLP)-1 receptor agonists and GLP-2 receptor agonists, studies have investigated the effects of these hormones on the enterohepatic circulation of bile acids and gallbladder motility. Results suggest, that bile acids and GLP-2 counteract postprandial cholecystokinin-mediated gallbladder contraction, while GLP-1 may delay gallbladder refilling. This provides important information on the effect and safety of drugs based on GLP-1 and GLP-2, respectively.
- Published
- 2018