1. [Common variable immunodeficiency can present as a multisystemic disorder].
- Author
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Jørgensen RM, Hansen AB, Cannon SV, and Peterslund NA
- Subjects
- Adolescent, Adult, Delayed Diagnosis, Humans, Immunoglobulins, Intravenous administration & dosage, Immunoglobulins, Intravenous therapeutic use, Immunologic Factors administration & dosage, Immunologic Factors therapeutic use, Male, Splenomegaly diagnostic imaging, Splenomegaly etiology, Common Variable Immunodeficiency complications, Common Variable Immunodeficiency diagnosis, Common Variable Immunodeficiency drug therapy
- Abstract
Common variable immunodeficiency is the second most common primary immunodeficiency with a prevalence of approx. 1/10.000-50.000. The clinical challenge is early diagnosis and efficient supportive treatment. The purpose of the present article is to focus on the complexity of the disease, including the risk of a long pre-diagnostic period and to focus on the sarcoidosis-like variant and the possible impact of immunoglobulin subclass deficiency.
- Published
- 2015