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Monkeypox is a viral zoonosis with symptoms that appear similar to smallpox patients seen in the past, although it is clinically less severe. Since eradicating smallpox in 1980, monkeypox has become the most important orthopoxvirus for public health. The virus is primarily transmitted by close contact with respiratory secretions, skin lesions of an infected person, or contaminated objects. We describe a young male with fever and vesicular rash diagnosed with monkeypox and herpes simplex virus 2 and review inpatient management of monkeypox infection.