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Highway construction has been played an important role in Chinese economic development. A good design was a key factor to a successful project, and at the same time, the geometric parameters and mechanical parameters of asphalt pavement both were of great weight. In this paper, a model of semi-rigid base and asphalt pavement was established, and load response was calculated with BISAR on base of three-layer system, comparison of impact of different parameters on the response was carried out to get the discipline, and this will help the designers to optimize design.