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Currently major challenge for scientists is to cope with Coronavirus infection that alters host immune response in different ways There is variability in immune response in diverse populations against this infection and particularly immunity of a certain population against SARS-CoV-2is not clear Many factors such as viral and host genetics that play crucial in this infection but immunological aspects are more important in infection and disease progression Its different patterns of spread and severity needs timely focus to design strategies against this disease This review sums up the concepts related to host immune response to SARS-CoV-2, cellular and humoral immunity, cytokines storm and immunization against COVID-19 [ABSTRACT FROM AUTHOR] Copyright of Biomedica is the property of Knowledge Bylanes and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission However, users may print, download, or email articles for individual use This abstract may be abridged No warranty is given about the accuracy of the copy Users should refer to the original published version of the material for the full abstract (Copyright applies to all Abstracts )