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Obesity leads to increased morbidity, disability, mortality and, crucially – decrease in the quality of life. As a tool for analyzing the quality of life, general nonspecific and specific questionnaires, preferring the latter are widely used. 97 patients with morbid obesity of III-IV class of operative-anesthetic risk according to the scale of the American Society of Anaesthesiologists were examined and treated. Two-stage treatment of patients was carried out as follows: in the patients of the main group intragastric balloon was used as thefirst stage for 6 months, patients of the control group were administered conservative therapy which included diet, physical activity and behavioral therapy. The quality of life was assessed using the Obesity and Weight-Loss Quality-of-Life Instrument (OWLQOL) -17 questionnaire. At the first stage, the mean percent of excess body weight loss % EWL in the main group was 22.69±5.87% being statistically significantly (p