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Abdulrahman M Jabour,1 Wajiha Rehman,1 Sumaira Idrees,1 Hemalatha Thanganadar,1 Kiani Hira,2 Mohammad A Alarifi3 1Department of Health Informatics, Faculty of Public Health and Tropical Medicine, Jazan University, Jazan, Saudi Arabia; 2Maternal, Neonatal and Child Health Research Network, Islamabad, Pakistan; 3Department of Radiological Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi ArabiaCorrespondence: Abdulrahman M JabourDepartment of Health Informatics, Faculty of Public Health and Tropical Medicine, Jazan University, Jazan, Saudi ArabiaTel +966-17329500 Ext 5545Email ajabour@jazanu.edu.saBackground: Studies documented the important role of health-care professionals in encouraging their patients to adopt and use mobile health applications. Health-care professionals who use and believe in mobile health applications are more likely to encourage and empower their patients to use it. Likewise, students in health-profession related specialties who use mobile health applications are more likely to continue to do so when they join the workforce.Objective: The objective of this study was to examine the rate of adoption of mobile health applications in students in health colleges, identify the types of health applications used by health students, and identify the barriers that prevent the use of mobile health applications.Methods: A descriptive cross-sectional study was conducted among university students. Students were invited to participate in a self-administrated survey from five health colleges. The survey included questions about the pattern of utilization, the purpose of the health-related application being used, and the barriers to adoption. The analysis included descriptive statistics using SPSS.Results: A total of 383 students participated in this study. The within gender comparison showed that more female students were using health-related applications 59.8% compared to male students 49%. The most frequent purpose of using mobile health applications were tracking physical activities 72.5% followed by counting calories intake 44%. We also identified the frequency and duration of use as well as the factors which may impact students intention to use.Conclusion: Fitness and dietary related applications were more common which might be explained by the fact that we only included a younger age group. The reported levels of perceived usefulness, accessibility and ease of use suggest that students will continue to use it.Keywords: mHealth, mobile phones, behavior change, health promotion, physical activity, nutrition, overweight, adolescents and students